N. A. Pikaar

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Thornton (1981) put forward the hypothesis that acidification of the colon by dietary fibre may prevent the degradation of bile acids or cholesterol into (co-)carcinogens and so may contribute to the prevention of colorectal cancer. This hypothesis might gain in importance if the colonic pH could be manipulated through diets without an excessive amount of(More)
In a metabolic ward 12 healthy male subjects consumed mixed Western (M), lacto-ovovegetarian (L), and vegan (V) diets in a randomized order for 20 d each. The concentrations of deoxycholic acid, isolithocholic acid, and total bile acids in 4-d composites of feces on the L and V diets were significantly lower than on the M diet. The(More)
A recently developed three-compartment model for the absorption and elimination of ingested alcohol was applied to re-analyse a study on the effects of various factors known to influence the blood-alcohol curve. The absorption and elimination of alcohol after drinking diluted alcohol were studied in healthy volunteers under strictly standardized conditions.(More)
The influence of several factors on the blood alcohol course after drinking diluted ethanol was studied in young, healthy volunteers under strictly standardized conditions. These factors were sex, dose and concentration of the alcohol, physical exercise immediately after drinking, meal consumption before drinking and energy content and composition of the(More)
Twelve young adult male volunteers were given a low-fibre white bread diet (9 g neutral-detergent fibre (NDF)/d) and a medium-fibre coarse-bran bread diet (22 g NDF/d), each lasting 20 d. In a third period of 20 d the volunteers were subdivided in groups of four, consuming a high-fibre coarse-bran bread diet (35 g NDF/d), a medium-fibre fine-bran diet (22 g(More)