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In order to try to determine whether differentiated olfactory receptors turn over (die and are replaced by newly differentiated cells) during adult life, mice were injected with a single dose of 3H-thymidine at either 2 or 4 months of age and allowed to survive for up to 12 months; they were caged in a laminar flow unit to prevent rhinitis. Counts of(More)
A quantitative study of the rat olfactory bulb during aging was carried out by directly measuring or calculating the following parameters at 3, 12, 24, 27, and 30 months: The volume of the glomerular, external plexiform, and internal granular layers, a relative measure of the size of the olfactory nerve layer, the mean volume of mitral cell nuclei and(More)
Quantitative measurements of the major organelles in the mitral cell perikaryon as well as numbers of mitral somato-dendritic synapses, have been made on electron micrographs from rats aged 3 to 30 months. The volume fraction of the cisternae of rough endoplasmic reticulum (RER) is constant throughout the period studied. Hence the amount of RER per cell(More)
Two regions closely linked synaptically (olfactory epithelium and olfactory bulb) have been compared in an age-graded series of rats. Previous findings of growth and atrophy of constituent elements in Sprague-Dawley Wisconsin (SD) rats have now been confirmed in Charles River (Crl) rats. In the olfactory bulbs of Charles River (Crl) rats, the volume of(More)
The population dynamics of internal granule cells in the rat olfactory bulb during adult life were analyzed in histological sections and in autoradiograms with (1) counts of granule cells, (2) counts of labeled granule cells 1 month after injection of 3H-thymidine at various ages, and (3) counts of labeled granule cells at varying survival times (up to 18(More)
Olfactory bulbs from Charles River (Crl) rats from 3 to 36 months have been examined with light and electron microscopy. Total capillary length, surface, and volume, as well as number of endothelial cells, increases during the twofold increase in olfactory bulb volume from 3 to 18 months, but the relative density of these parameters shows no change during(More)
Previous studies have quantified growth and atrophy of the olfactory bulb and olfactory epithelium of the Sprague-Dawley rat from maturity to senescence. Major events occurring in these structures include changes in the volume of mitral cells and changes in the number of septal olfactory receptors. These effects are large, consist of a growth phase followed(More)
Dispersion of cisternae of rough endoplasmic reticulum (RER) in aging rats has been determined quantitatively for mitral cells of the olfactory bulb and Purkinje cells of the cerebellum using a recently published morphometric technique (Cruz Orive, '76). In both cell types dispersion of cisternae occurred throughout the period studied and in a linear(More)
Intranuclear inclusions have been observed in layer II neurons of rat piriform cortex. These inclusions have the form of a filamentous lattice and resemble those described by others previously. The frequency of lattice-containing nuclei shows a significant fourfold increase over a period of 3-33 months of age, with the largest increase occurring after 18(More)
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