N. A. Martynova

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Acute cold stress induced lymphocyte activating factor production by peritoneal macrophages and elevation of blood corticosterone concentration in the rat, while lysosomecation indices significantly decreased. Multiple cold stimuli initiated lymphocyte activating factor production by peritoneal macrophages in the rat, but corticosterone blood concentration(More)
White rat experiments were made to study healing of cutaneous wounds in acute and chronic alcohol-substitute intoxications. Physico-morphological, bacterioscopic and cytochemical examinations showed that oral introduction of ethanol, methanol and their mixture inhibited healing of the wounds due to suppuration.
The toxic properties of indole have been studied in terms of LD50 indole was established to refer to moderately hazardous substances: in case of indole introducing into the stomach in rats and mice, DL50 is 1200 mg/kg and 750 mg/kg respectively Indole has a weak ability to cumulation, and has a strong irritant effect to the eyes and a moderate one to the(More)
Experiments on laboratory animals studied toxic effects of benzofuran derivatives obtained during anti-arrythmic drug Amiodarone production. Toxic effects were studied for single and subacute intake through intragastric, inhalation and epicutaneous routes. Recommendations are given for hygienic regulation of Amiodarone and intermediate products of its(More)
The influence of an original substance based on enzymatically destructed alginic acid on the reparative activity has been studied using an experimental model of planar aseptic wound. Toxicity of the test compound was evaluated and its effective dose was determined using curiozin as the reference drug. It is found that the test compounds is non-toxic. It is(More)
Toxic properties of sulpiride were studied with an aim of its hygienic standardization. LD50 of sulpiride in administration into the stomach of male rats and mice is 7200 and 3400 mg/kg, for female rats and mice - 6000 and 2300 mg/kg. It refers to substances of hazard Classes 3, 4. No significant differences were noted in the species and sex sensitivity of(More)