N. A. Khristolyubova

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The children of alcoholism patients have a high biological risk of this illness, mental and emotional disorders, and behavioral disturbances. The offspring of white mongrel rats with chronic alcohol intoxication were investigated in order to study the neurochemical mechanisms of these phenomena. The content of DA in blood and blood plasma, the(More)
Mechanisms of genetically determined alcoholic motivation were studied in chronically alcohol treated rats and their offspring using neurochemical, physiological and genetic techniques. Stimulation of the activity of membrane-bound monoamine oxidases, (e.g., in liver or brain), modification of their catalytic properties, partial solubilisation and increased(More)
The effect of sulfated octapeptide of cholecystokinin (CCK) on dopamine turnover was examined in different parts of the rat brain. It was demonstrated that CCK administered intrapeutoneally in doses of 5, 15 and 30 micrograms/kg significantly increased dopamine turnover in the amygdala, and nucleus accumbeus, without changing dopamine turnover in the(More)
The effect of a single administration of the endogenous peptide substance P on the content of dopamine (DA), and norepinephrine (NE), and on the activity of tyrosine hydroxylase (TH) and dopamine β-hydroxylase (D-β-H) is studied in the hypothalamus and midbrain of rats after a 6-month alcoholization.
A definite increase in the content of eateeholamines was constantly observed in the mesencephalic re t icu la r formation at the level of the caudal two-thirds of the interpeduneular nucleus, in the substantia nigra, in the zone above the interpeduncular nucleus at the level of its middle third, and in an area situated la teral ly to the interpeduncular(More)
In the liver mitochondrial fraction of the first generation offspring of alcoholized male rats, decreased activities of monoamine oxidase (MAO) types A and B, rotenone-insensitive NADH-cytochrome c-reductase and succinate dehydrogenase were observed. The MAO-dependent inhibition of rotenone-insensitive NADH-cytochrome c-reductase and succinate dehydrogenase(More)
A system of neurochemical signs indicating predisposition to high ethanol consumption is formed in the third generation descendants of ethanol-preferring male rats. Risk-group males are detected (with 95% probability) by the content of dopamine and norepinephrine and their ratio in the brain. Alcohol motivation depends on blood epinephrine content(More)
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