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A connection between pineal function and several psychiatric diseases has been shown recently. The diurnal and seasonal rhythmicity of melatonin production is associated with affective disorders and several types of endogenous depression. The cortisolmelatonin ratio was significantly higher in depressed individuals than in healthy controls. Alterations in(More)
Electron microscopy of an amphophil pituitary adenoma surgically removed from a 51-year-old woman who had Nelson's syndrome revealed that the tumor was composed of melanocorticotroph cells. This finding is consistent with the view that in the human pituitary gland one single cell type produces both adrenocorticotropic hormone (ACTH) and(More)
The pineal gland produces many neurohormones that affect the function of the brain. One of these hormones, melatonin among other functions, shows oncostatic properties against some malignant tumors. Our investigations confirmed the oncostatic effect of this compound based on (a) the measurements of melatonin in the serum of melanoma patients, (b)(More)
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