N. A. Baranova

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Screening for producers of proteinases with fibrinolytic (plasmin-like and plasminogen-activating) and collagenolytic activities was carried out among 83 strains of microscopic fungi belonging to various ecological groups. Entomopathogenic micromycetes secreted proteinases with higher fibrinolytic and collagenolytic activity than saprotrophic, potentially(More)
The effect of lovastatin, a competing inhibitor of 3-hydroxy-3-methylglutaryl-CoA-reductase (HMG-CoA-reductase) of the fungal origin on the growth of and ergosterol biosynthesis by Rh. rubra VKPM Y 1337 was studied. It was shown that the yeast growth was inhibited by lovastatin in concentrations of 0.25 to 5.0 micrograms/ml when the inhibitor was added to(More)
The effect of various xenobiotic substrates of microsomal cytochrome P-450, including dimethylaniline, ethylmorphine, hexabarbital and aminopyrine, on the bioluminescence of the bacteria Vibrio fischeri and the bacterial luciferase mixed-function oxidase system is described. These compounds are effective inhibitors of the luminescence reaction. The(More)
The micromycetes of the Aspergillus genus were screened for the evaluation of their capacity to secrete extracellular proteolytic enzymes effecting proteins of the human hemostatic system. Aspergillus extracellular proteases were found to cleave chromogenic peptide substrates specific for the hemostatic proteins, as well as to activate some proenzymes(More)
The hemoprotein composition of the luminescent bacterium Photobacterium fischeri was studied, in particular, the distribution of cytochromes among the bacterial fractions, viz. cell-free extract, supernatant, "particles", protein preparation. The hemochromogenic analysis has shown that the principal hemoproteins of Photobacterium fischeri are cytochromes,(More)
It was shown that under definite conditions there was competition between natural variants of sea bacteria belonging to V. fischeri. Natural variants of V. fischeri, strain 6 differed in their resistance to streptomycin and had different growth rates under conditions of limited aeration. Morphologically all the variants were identical. V. fischeri P-0, V.(More)
The conditions for the submerged and solid-state fermentation of the micromycete Aspergillus ochraceus VKM F-4104D, producing extracellular proteinases that activate protein C of human blood plasma, were optimized. It is shown that the protein C-activating activity of the micromycete in a solid-state culture was 1.5-3.5 times higher than in a submerged(More)
The properties of an extracellular proteinase activating plasma protein C isolated from the culture supernatant of Aspergillus ochraceus VKM F-4104D have been studied. This enzyme demonstrated a substrate specificity absent of hydrolyzing activity toward chromogenic proteinase substrates. On the basis of inhibitory analysis, the protein C-activating(More)
Lovastatin (monocolin K) is a competitive inhibitor of 3-hydroxy-3-methylglutaryl-CoA-reductase. Its influence on the growth of a lovastatin sensitive strain of Rhodotorula rubra, the biosynthesis of ergosterol and the resistance to polyenic antibiotics was studied. It was shown that the lovastatin action on the strain depended on the inhibitor dose. In a(More)