Nélida M. Conejo

Jorge L Arias15
Héctor González-Pardo10
Raúl Cantora3
15Jorge L Arias
10Héctor González-Pardo
3Raúl Cantora
3Matías López
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Aging is associated with insulin resistance, which represents a common factor in age-related diseases. We aimed to determine the role of 17beta-estradiol on insulin sensitivity and memory during aging using ovariectomized rats (2-26 months of age) treated with physiological doses of 17beta-estradiol. Our results indicate a lack of effect of 17beta-estradiol(More)
  • José M Cimadevilla, Nélida M Conejo, Rubén Miranda, Jorge L Arias, Diferencias Sexuales
  • 2004
skills are used to be able to adapt to an ever-changing environment. For thousands of years, spatial memory has contributed to our knowledge and exploration of the available resources in our surroundings. Spatial tasks reveal different abilities in male and female rats, although using different protocols, tasks, species and ages has produced variable(More)
In view of the inconclusive findings relating the nuclei of the mammillary bodies (MB) with spatial memory, we evaluated the oxidative metabolic activity of the medial and lateral nuclei of the mammillary bodies (MB) after training young rats (30 days) of both sexes in the Morris water maze. Different groups were trained in spatial working (WM) or reference(More)
The aim of the present study was to provide further evidence on the role of particular subdivisions of the mammillary bodies, anterior thalamus and dorsal hippocampus to contextual and auditory fear conditioning. We used c-Fos expression as a marker of neuronal activation to compare rats that received tone-footshock pairings in a distinctive context(More)
The effects of classical fear conditioning in different regions of the limbic system were analysed using cytochrome oxidase (CO) histochemistry. Wistar rats were submitted to different conditions. Rats in the group Paired received tone-shock pairing, to elicit conditioned suppression of lever pressing (i.e., tone will evoke conditioned fear responses). The(More)
We quantified the number of glial fibrillary acidic protein immunoreactive (GFAP-IR) astrocytes in the CA1 and CA3 areas of the adult rat hippocampus. The dorsal and ventral regions of the hippocampus were taken into account to estimate the GFAP-IR cells using unbiased stereological techniques. Males had a higher number of GFAP-IR astrocytes in the CA3(More)
Alcoholism is one of the most important problems today. Chronic alcohol intake produces many cognitive deficits in humans, especially in memory. To evaluate the memory deficits in alcoholism it is very common to use animal models. In the present work, rats receiving chronic alcohol intake and not submitted to withdrawal were evaluated in a spontaneous(More)
Previous studies showed the involvement of brain regions associated with both spatial learning and associative learning in spatial memory extinction, although the specific role of the dorsal and ventral hippocampus and the extended hippocampal system including the mammillary body in the process is still controversial. The present study aimed to identify the(More)
Several studies suggest a prefrontal cortex involvement during the acquisition and consolidation of spatial memory, suggesting an active modulating role at late stages of acquisition processes. Recently, we have reported that the prelimbic and infralimbic areas of the prefrontal cortex, among other structures, are also specifically involved in the late(More)
Several studies have reported the brain regions involved in response learning. However, there is discrepancy regarding the lighting conditions in the experimental setting (i.e. under dark or light conditions). In this regard, it would be relevant to know if the presence/absence of visual cues in the environment has any effect in the brain networks involved(More)