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In the spirit of adventure that has been characteristic of our Society, I am going to ask you to join me in a mental journey. The purpose is to try to look at something familiar in a new way. We are going to be looking at bereavement—something you all know a lot about—and I am going to try to get a different perspective on it by using information gathered(More)
In Experiment 1, 3-6-day-old rats were simultaneously exposed to an unfamiliar odor which they will normally avoid (orange extract) and the odor of maternal saliva, or to either orange alone or saliva alone. One hour later, in a two-odor choice test, those pups which were simultaneously exposed to orange and saliva exhibited an enhanced orientation to the(More)
BACKGROUND As a key regulator of serotonergic activity and target of many antidepressant treatments, the serotonin transporter (SERT) represents a potential mediator of anxiety- and depression-related behaviors. Using mice lacking the SERT (SERT KO), we examined the role of SERT function in anxiety- and depression-related behaviors and serotonergic neuron(More)
This article outlines a strategy for studying early social relationships in relatively simple animal model systems. It describes some of the differences in approach between neuroscientists and human developmentalists in dealing with the same research problems. These ideas are then illustrated in work from our laboratory on the processes of early social(More)
Recently captured wild rodents of six different species were tested in a standard "open field" arena where they were subjected to sudden visual and auditory stimulation as well as to a natural predator. Periods of prolonged immobility ranging from 2 to more than 60 minutes' duration were elicited in 21 members of four species. This behavioral state was(More)
In Part I of this study maternal behavior of 15 spontaneously hypertensive (SHR) and 11 Wistar-Kyoto (WKY) rat mothers was recorded throughout the preweaning period. SHR mothers were observed: 1) in arched-and blanket-nursing postures more often, and in passive-nursing posture less often, 2) licking their pups more often, and 3) resting less often. Further,(More)
This study tested whether mothers with interpersonal violence-related posttraumatic stress disorder (IPV-PTSD) vs healthy controls (HC) would show greater limbic and less frontocortical activity when viewing young children during separation compared to quiet play. Mothers of 20 children (12-42 months) participated: 11 IPV-PTSD mothers and 9 HC with no PTSD.(More)
This study describes the development of anxiety and motor activation in mice lacking the serotonin (5HT) 1B receptor and in wild type controls and characterizes their early mother-infant interactions. In the isolation-induced ultrasonic vocalization paradigm, 5HT1B knockout pups vocalized less and were hyperactive, rearing, jumping, and rolling more often(More)
Several of the recently characterized neuroactive steroids have been proposed to have anxiolytic effects in behavioral models when subjects were tested as adults. In this experiment, the effects on infant subjects were examined using the isolation distress model of anxiety. The production of ultrasonic vocalizations in week-old rat pups after maternal(More)