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- Publications
- Influence
Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation
- S. Chen, Srdja Drakulic, +16 authors N. Cremades
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences
- 8 April 2015
Significance Certain oligomeric species generated during the self-assembly of specific proteins into ordered fibrillar aggregates are likely to be key players in the initiation and spreading of… Expand
Conserved Amphipathic Helices Mediate Lipid Droplet Targeting of Perilipins 1–3*
- Emily R Rowe, M. Mimmack, +8 authors D. Savage
- Biology, Medicine
- The Journal of Biological Chemistry
- 7 January 2016
Perilipins (PLINs) play a key role in energy storage by orchestrating the activity of lipases on the surface of lipid droplets. Failure of this activity results in severe metabolic disease in humans.… Expand
Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein
- Céline Galvagnion, James W. P. Brown, +5 authors C. M. Dobson
- Medicine, Chemistry
- Proceedings of the National Academy of Sciences
- 13 June 2016
Significance Parkinson’s disease is the second most prevalent neurodegenerative disorder and is characterized by the presence in the brains of patients of proteinaceous deposits whose main component… Expand
Effect of the interplay between protein and surface on the properties of adsorbed protein layers
- Myriam M. Ouberai, K. Xu, M. Welland
- Materials Science, Medicine
- Biomaterials
- 1 August 2014
Although protein adsorption to surface is a common phenomenon, investigation of the process is challenging due to the complexity of the interplay between external factors, protein and surface… Expand
α-Synuclein Senses Lipid Packing Defects and Induces Lateral Expansion of Lipids Leading to Membrane Remodeling*
- Myriam M. Ouberai, J. Wang, +4 authors M. Welland
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 5 June 2013
Background: α-Synuclein folds into an amphipathic α-helical structure upon membrane interaction. Results: The binding is promoted by lipid packing defects found in vesicles of high curvature and in… Expand
A comprehensive study of lysozyme adsorption using dual polarization interferometry and quartz crystal microbalance with dissipation.
- K. Xu, Myriam M. Ouberai, M. Welland
- Materials Science, Medicine
- Biomaterials
- 1 February 2013
Protein adsorption plays a crucial role in biomaterial surface science as it is directly linked to the biocompatibility of artificial biomaterial devices. Here, elucidation of protein adsorption… Expand
Serum protein layers on parylene-C and silicon oxide: Effect on cell adhesion
- E. Delivopoulos, Myriam M. Ouberai, Paul D Coffey, M. J. Swann, K. Shakesheff, M. Welland
- Chemistry, Medicine
- Colloids and surfaces. B, Biointerfaces
- 1 February 2015
Graphical abstract
Controlling the bioactivity of a peptide hormone in vivo by reversible self-assembly
- Myriam M. Ouberai, A. L. G. dos Santos, +12 authors M. Welland
- Chemistry, Medicine
- Nature Communications
- 18 October 2017
The use of peptides as therapeutic agents is undergoing a renaissance with the expectation of new drugs with enhanced levels of efficacy and safety. Their clinical potential will be only fully… Expand
Polymeric nanobiotics as a novel treatment for mycobacterial infections
- I. L. Batalha, A. Bernut, +10 authors R. Floto
- Medicine
- Journal of controlled release : official journal…
- 28 November 2019
Graphical abstract
Two-Step Membrane Binding of NDPK-B Induces Membrane Fluidity Decrease and Changes in Lipid Lateral Organization and Protein Cluster Formation.
- L. François-Moutal, Myriam M. Ouberai, +7 authors T. Granjon
- Chemistry, Medicine
- Langmuir : the ACS journal of surfaces and…
- 22 November 2016
Nucleoside diphosphate kinases (NDPKs) are crucial elements in a wide array of cellular physiological or pathophysiological processes such as apoptosis, proliferation, or metastasis formation. Among… Expand