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Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation
Significance Certain oligomeric species generated during the self-assembly of specific proteins into ordered fibrillar aggregates are likely to be key players in the initiation and spreading ofExpand
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Conserved Amphipathic Helices Mediate Lipid Droplet Targeting of Perilipins 1–3*
Perilipins (PLINs) play a key role in energy storage by orchestrating the activity of lipases on the surface of lipid droplets. Failure of this activity results in severe metabolic disease in humans.Expand
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Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein
Significance Parkinson’s disease is the second most prevalent neurodegenerative disorder and is characterized by the presence in the brains of patients of proteinaceous deposits whose main componentExpand
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Effect of the interplay between protein and surface on the properties of adsorbed protein layers
Although protein adsorption to surface is a common phenomenon, investigation of the process is challenging due to the complexity of the interplay between external factors, protein and surfaceExpand
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α-Synuclein Senses Lipid Packing Defects and Induces Lateral Expansion of Lipids Leading to Membrane Remodeling*
Background: α-Synuclein folds into an amphipathic α-helical structure upon membrane interaction. Results: The binding is promoted by lipid packing defects found in vesicles of high curvature and inExpand
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A comprehensive study of lysozyme adsorption using dual polarization interferometry and quartz crystal microbalance with dissipation.
Protein adsorption plays a crucial role in biomaterial surface science as it is directly linked to the biocompatibility of artificial biomaterial devices. Here, elucidation of protein adsorptionExpand
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Serum protein layers on parylene-C and silicon oxide: Effect on cell adhesion
Graphical abstract
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Controlling the bioactivity of a peptide hormone in vivo by reversible self-assembly
The use of peptides as therapeutic agents is undergoing a renaissance with the expectation of new drugs with enhanced levels of efficacy and safety. Their clinical potential will be only fullyExpand
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Polymeric nanobiotics as a novel treatment for mycobacterial infections
Graphical abstract
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Two-Step Membrane Binding of NDPK-B Induces Membrane Fluidity Decrease and Changes in Lipid Lateral Organization and Protein Cluster Formation.
Nucleoside diphosphate kinases (NDPKs) are crucial elements in a wide array of cellular physiological or pathophysiological processes such as apoptosis, proliferation, or metastasis formation. AmongExpand
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