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Reversing the Warburg Effect as a Treatment for Glioblastoma*
Background: Glioblastoma is the most prevalent brain tumor with the poorest prognosis. Results: Methylene blue enhances oxygen consumption, reduces lactate production, and inhibits glioblastoma cellExpand
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Pyruvate Protects the Brain Against Ischemia–Reperfusion Injury by Activating the Erythropoietin Signaling Pathway
Background and Purpose— Pyruvate is known to be cytoprotective through antioxidant and anti-inflammatory mechanisms. We tested the hypothesis that pyruvate protects the brain againstExpand
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Involvement of p38 MAPK in reactive astrogliosis induced by ischemic stroke
Reactive astrogliosis is an essential feature of astrocytic response to all forms of central nervous system (CNS) injury and disease, which may benefit or harm surrounding neural and non-neuralExpand
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Involvement of estrogen receptor β5 in the progression of glioma
Emerging evidence suggests a decline of ERβ expression in various peripheral cancers. ERβ has been proposed as a cancer brake that inhibits tumor proliferation. In the current study, we haveExpand
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Erythropoietin: Powerful protection of ischemic and post-ischemic brain
Ischemic brain injury inflicted by stroke and cardiac arrest ranks among the leading causes of death and long-term disability in the United States. The brain consumes large amounts of metabolicExpand
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HIV-1 Nef Is Transferred from Expressing T Cells to Hepatocytic Cells through Conduits and Enhances HCV Replication
HIV-1 infection enhances HCV replication and as a consequence accelerates HCV-mediated hepatocellular carcinoma (HCC). However, the precise molecular mechanism by which this takes place is currentlyExpand
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In vitro protection by pyruvate against cadmium‐induced cytotoxicity in hippocampal HT‐22 cells
Cadmium is a toxic metal with no biological function in higher‐order mammals. Humans are exposed to cadmium environmental contamination and the mechanism underlying the cadmium's cytotoxicity isExpand
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An In Vitro Oxygen-Glucose Deprivation Model for Studying Ischemia-Reperfusion Injury of Neuronal Cells.
Ischemia-reperfusion syndromes of the heart and brain are the leading cause of death and long-term disability worldwide. Development of effective treatments for myocardial infarction, stroke, cardiacExpand
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Featured Article: Pyruvate preserves antiglycation defenses in porcine brain after cardiac arrest
Cardiac arrest (CA) and cardiocerebral resuscitation (CCR)-induced ischemia–reperfusion imposes oxidative and carbonyl stress that injures the brain. The ischemic shift to anaerobic glycolysis,Expand
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Pyruvate-fortified cardioplegia suppresses oxidative stress and enhances phosphorylation potential of arrested myocardium.
Cardioplegic arrest for bypass surgery imposes global ischemia on the myocardium, which generates oxyradicals and depletes myocardial high-energy phosphates. The glycolytic metabolite pyruvate, butExpand
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