Myles Mc Laughlin

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The medial nucleus of the trapezoid body (MNTB) receives excitatory input from giant presynaptic terminals, the calyces of Held. The MNTB functions as a sign inverter giving inhibitory input to the lateral and medial superior olive, where its input is important in the generation of binaural sensitivity to cues for sound localization. Extracellular(More)
A popular model of binaural processing, proposed by Jeffress (1948), states that external interaural time delays (ITDs) are compensated by internal axonal delays allowing ITD to be spatially represented by a population of coincidence detectors in the medial superior olive (MSO). Isolating single-neuron responses in MSO is difficult because of the presence(More)
Frequency selectivity in the inner ear is fundamental to hearing and is traditionally thought to be similar across mammals. Although direct measurements are not possible in humans, estimates of frequency tuning based on noninvasive recordings of sound evoked from the cochlea (otoacoustic emissions) have suggested substantially sharper tuning in humans but(More)
A defining feature of auditory systems across animal divisions is the ability to sort different frequency components of a sound into separate neural frequency channels. Narrowband filtering in the auditory periphery is of obvious advantage for the representation of sound spectrum and manifests itself pervasively in human psychophysical studies as the(More)
To localize low-frequency sounds, humans rely on an interaural comparison of the temporally encoded sound waveform after peripheral filtering. This process can be compared with cross-correlation. For a broadband stimulus, after filtering, the correlation function has a damped oscillatory shape where the periodicity reflects the filter's center frequency and(More)
Local field potentials are important indicators of in vivo neural activity. Sustained, phase-locked, sound-evoked extracellular fields in the mammalian auditory brainstem, known as the auditory neurophonic, reflect the activity of neurons in the medial superior olive (MSO). We develop a biophysically based model of the neurophonic that accounts for features(More)
Until now, there are no clinically useful minimally invasive techniques for continuously monitoring regional arterial blood flow. Commercial intra-vascular Doppler wire (IVDW) pulsed wave systems only estimate flow velocities and are highly dependent on wire position. Measurement of true volumetric arterial flow (Q) requires the flow velocity distribution(More)
Transcranial alternating current stimulation (tACS) uses sinusoidal, subthreshold, electric fields to modulate cortical processing. Cortical processing depends on a fine balance between excitation and inhibition and tACS acts on both excitatory and inhibitory cortical neurons. Given this, it is not clear whether tACS should increase or decrease cortical(More)
Evoking motor potentials are an objective assessment method for neuromotor function, yet this was to our knowledge never done in neonatal lambs. There is neither a method for standardized quantification of motor evoked potentials (MEPs). We first aimed to evaluate the feasibility of MEP recording in neonatal lambs and test its validity. Second we aimed to(More)
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