Mylen Potier

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PURPOSE Age-related macular degeneration (ARMD) is characterized by progressive thickening and accumulation of various lipid-rich extracellular matrix (ECM) deposits under the retinal pigment epithelium (RPE). ECM dysregulation probably contributes to the pathologic course of ARMD. By activating estrogen receptors (ERs), estrogens regulate the expression of(More)
Diabetic glomerulosclerosis is characterized by the accumulation of extracellular matrix (ECM) in the mesangium. Estrogens seem to retard whereas estrogen deficiency seems to accelerate progressive glomerulosclerosis. Thus, mesangial cells (MC) may be a target for estrogens. Estrogen action is mediated via estrogen receptor (ER) subtypes ERalpha and ERbeta.(More)
Inositol 1,4,5-trisphosphate (InsP3) is an intracellular messenger generated upon stimulation of a wide variety of cells by Ca2(+)-mobilizing stimuli. Specific binding sites for InsP3 have been identified in the adrenal cortex and many other tissues. The purpose of the present study was to solubilize and further characterize InsP3 receptors of bovine(More)
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