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Proceeding from the fact that some widely used antibacterial preparations (furacilin, furazolidone, ftivazide) contain hydrazone groups, we decided to synthesize a series of pyrazole-4-carboxylic acid hydrazides, modify these compounds so as to obtain N-(4-pyrazoyl)hydrazones, and study the antibacterial properties of the products. Hydrazides IIIa – IIIg(More)
The influence of new derivatives of 9,10-anthraquinone with benzoylthiourea, thiazole, triazole and amino acid fragments on the activity of membrane-associated tyrosine kinases was investigated. Inhibitors of protein tyrosine kinase activity of the membrane fraction, as promising agents to search for new potential anticancer agents among the studied(More)
Hydrazones of aliphatic and aromatic carbonyl compounds are known to possess high biological activity [ 1 4 ] and are used in the production of some pharmaceuticals [5, 6]. It was reported that 3-bromo-4-alkoxyphenylacetyl hydrazones possess mutagenic and antitumor properties [7], while N-isonicotinoyl hydrazones produce antibacterial effects [8, 9].(More)
Ischemic stroke is one of the most severe brain pathologies that is extremely difficult to treat. Recently it has been found that acidosis accompanying cerebral ischemia induces activation of acid-sensing ion channel ASIC1a which results in its turn in the neuronal death. Here we present novel derivatives of 3-carboxamidinocoumarines that effectively(More)
The identification and study of nontraditional cardiotonic compounds is a matter of urgency in contemporary pharmacology and pharmacy [2]. Pyrimidines, imidazoles, phthalazines, polypeptides, and arylalkylamines are known which possess positive inotropic activity [i, 3, 4]. Cardiotonic activity has also been found in some condensed imidazothiazoles [i].(More)
Pd(I) and Ni(II) complex compounds: [Pd(AMMT)2]Cl2 (1), [Pd(AMMT)4]Cl2 (2) and [Ni(AMMT)2(H2O)](NO3)2 (3) with 4-amino-3-mercapto-5-methyl-1,2,4-triazole (AMMT) have been synthesized. The spectral characteristics of 1, 2 were studied by 1H (13C) NMR and UV-Vis spectroscopy. X-ray diffraction studies established that all complexes contain the AMMT molecule,(More)
The regioselective base-catalyzed addition of nitromethane to 2-oxo-4-trifluoromethyl-1,2-dihydropyrimidine-5-carboxylates is reported. It was found that the Michael-like pathway is highly reversible and substantially dominating under conditions of kinetic control (0-5 °C, 10 h) whereas the aza-Henry reaction leads to thermodynamically stable adducts after(More)
Methyl-3-{[2-(dimethylamino)propyl]amino}acrylate reacted with α-chloro-3-bromobenzylisocyanate to synthesize 4-(3-bromophenyl)-5-methoxycarbonyl-1-(N,N-dimethylaminopropyl)-3,4-dihydropyrimidin-2(1H)-one hydrochloride, alkylation of which by chloroacetate esters yielded a series of quaternary ammonium salts. The structures of the compounds were confirmed(More)
Heterocyclic compounds of the pyrazole series exhibit a broad spectrum of pharmacological activity [1, 2]. For example, 4-alkinylpyrazoles [3] and pyrazolyl-4-methylcarbamates [4] were reported to possess high antiinflammatory activity. Amides of substituted pyrazole-4-carboxylic and pyrazole-4-acetic acids are capable of inhibiting the activity of alcohol(More)