Mykhaylo V Vovk

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Proceeding from the fact that some widely used antibacterial preparations (furacilin, furazolidone, ftivazide) contain hydrazone groups, we decided to synthesize a series of pyrazole-4-carboxylic acid hydrazides, modify these compounds so as to obtain N-(4-pyrazoyl)hydrazones, and study the antibacterial properties of the products. Hydrazides IIIa – IIIg(More)
Ischemic stroke is one of the most severe brain pathologies that is extremely difficult to treat. Recently it has been found that acidosis accompanying cerebral ischemia induces activation of acid-sensing ion channel ASIC1a which results in its turn in the neuronal death. Here we present novel derivatives of 3-carboxamidinocoumarines that effectively(More)
The influence of new derivatives of 9,10-anthraquinone with benzoylthiourea, thiazole, triazole and amino acid fragments on the activity of membrane-associated tyrosine kinases was investigated. Inhibitors of protein tyrosine kinase activity of the membrane fraction, as promising agents to search for new potential anticancer agents among the studied(More)
Four novel Pd2+ and Pt2+ mononuclear π-coordination compounds with general formula [M(HL)1,2Cl2], M=Pd2+, Pt2+ have been synthesized by reaction of [PdCl4]2-, [PtCl4]2- anions with N-allyl-4-morpholinethiocarboxamide (HL1) and N-Allyl-N'-tert-butylthiourea (HL2). All complexes have been characterized by single-crystal X-ray diffraction study and 1H, 13C NMR(More)
Pd(I) and Ni(II) complex compounds: [Pd(AMMT)2]Cl2 (1), [Pd(AMMT)4]Cl2 (2) and [Ni(AMMT)2(H2O)](NO3)2 (3) with 4-amino-3-mercapto-5-methyl-1,2,4-triazole (AMMT) have been synthesized. The spectral characteristics of 1, 2 were studied by 1H (13C) NMR and UV-Vis spectroscopy. X-ray diffraction studies established that all complexes contain the AMMT molecule,(More)
A series of 2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbamides were synthesized by a three-component condensation of acetoacetamides, aromatic aldehydes, and thiourea. Their structures were confirmed by IR and PMR spectroscopy and mass spectrometry. Compounds exhibiting high inhibitory activity against superoxide generation by mitochondria in the liver and(More)
Interaction of 2-chloro-N-(9,10-dioxo-9,10-dihydroanthracen-1-yl)acetamide with α-, β- and ω-amino acids was used to synthesize new amino-acid derivatives of 9,10-anthraquinone. Experimental testing of the antimicrobial actions of the compounds synthesized demonstrated antibacterial activity against Mycobacterium luteum and antifungal activity against(More)
A series of new N-benzyl-N-(4-pyrazolylmethyl)benzenesulfamides has been synthesized by acylation of N-benzyl-N-(4-pyrazolylmethyl) amines with benzenesulfochlorides. The structures of the target products were established by elemental analysis and 1H NMR spectroscopy. The synthesized compounds show moderate antimicrobial activity.
Methyl-3-{[2-(dimethylamino)propyl]amino}acrylate reacted with α-chloro-3-bromobenzylisocyanate to synthesize 4-(3-bromophenyl)-5-methoxycarbonyl-1-(N,N-dimethylaminopropyl)-3,4-dihydropyrimidin-2(1H)-one hydrochloride, alkylation of which by chloroacetate esters yielded a series of quaternary ammonium salts. The structures of the compounds were confirmed(More)
A series of thiosemicarbazones, the structures of which were established by IR and PMR spectroscopy and mass spectrometry, were synthesized by condensation of 4-chloro-1H-imidazole-5-carbaldehydes with thiosemicarbazide. Some of the synthesized compounds were found to exhibit high inhibitory activity with respect to M. tuberculosis strains that was 1.5(More)