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Ca2+ Entry, Oxidative Stress, Ceramide and Suicidal Erythrocyte Death Following Diosgenin Treatment
TLDR
Whether diosgenin induces eryptosis and, if so, to decipher cellular mechanisms involved is explored, an effect paralleled by and at least in part due to Ca2+ entry, oxidative stress and ceramide.
Triggering of Erythrocyte Cell Membrane Scrambling by Emodin
TLDR
Whether emodin induces eryptosis and, if so, to elucidate underlying cellular mechanisms is tested, an effect at least in part due to stimulation of Ca2+ entry and paralleled by oxidative stress and ceramide appearance at the erythroctye surface is triggered.
Stimulation of Suicidal Erythrocyte Death by the CDC25 Inhibitor NSC-95397
TLDR
Whether NSC-95397 induces eryptosis is explored and, if so, to shed some light on the mechanisms involved, an effect in part requiring entry of Ca2+ and activation of staurosporine sensitive kinase(s).
Stimulation of Suicidal Erythrocyte Death by Rottlerin
TLDR
Whether rottlerin induces eryptosis and, if so, to test for the involvement of Ca2+ entry and ceramide, and how this affects cell shrinkage and phospholipid scrambling of the erythrocyte cell membrane are explored.
Stimulation of Erythrocyte Cell Membrane Scrambling by Quinine
TLDR
Quinine triggers phospholipid scrambling of the erythrocyte cell membrane, an effect at least in part due to Ca2+ entry, oxidative stress, ceramide and D4476 sensitive casein kinase.
Triggering of Suicidal Erythrocyte Death by Fascaplysin
TLDR
Whether Fascaplysin induces eryptosis and, if so, to shed light on the cellular mechanisms involved is explored, an effect at least in part due to Ca2+ entry, oxidative stress and ceramide.
Stimulation of Suicidal Erythrocyte Death by Phosphatase Inhibitor Calyculin A
TLDR
Calyculin A triggers cell shrinkage and phospholipid scrambling of the erythrocyte cell membrane, an effect at least in part requiring Ca2+ entry, kinase activity and caspase activation.
Camalexin-Induced Cell Membrane Scrambling and Cell Shrinkage in Human Erythrocytes
TLDR
Whether Camalexin induces eryptosis and, if so, to shed light on mechanisms involved is explored, an effect at least in part depending on Ca2+ entry, as well as staurosporine and chelerythrine sensitive kinase(s).
Stimulation of Erythrocyte Cell Membrane Scrambling by Adarotene
TLDR
Adarotene stimulates phospholipid scrambling of the erythrocyte cell membrane, an effect paralleled by and at least in part due to Ca2+ entry, oxidative stress and ceramide.