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Uniparental disomy in cancer.
Constitutional UPD is associated with meiotic errors, resulting in developmental diseases, whereas acquired UPD probably occurs as a result of a mitotic error in somatic cells, which can be an important step in cancer development and progression.
High quality copy number and genotype data from FFPE samples using Molecular Inversion Probe (MIP) microarrays
High quality CN data with MIP technology was generated in 88% of FFPE samples from seven diverse collections and the performance of F FPE DNA was comparable to that of DNA obtained from matched frozen tumor (genotype concordance averaged 99.9%).
Downregulation of Wilms' tumor 1 protein inhibits breast cancer proliferation.
- P. Zapata-Benavides, Musaffe Tuna, G. Lopez-Berestein, A. Tari
- MedicineBiochemical and biophysical research…
- 26 July 2002
Using liposome-incorporated WT1 antisense oligodeoxynucleotides, it is found that downregulation of WT1 protein expression led to breast cancer growth inhibition and reduced cyclin D1 protein levels, indicating that WT1protein contributes to breast cancers progression by promoting breast cancer cell proliferation.
HER2/neu increases the expression of Wilms' Tumor 1 (WT1) protein to stimulate S-phase proliferation and inhibit apoptosis in breast cancer cells
The data indicate that HER2/neu engages Akt to increase WT1 expression, and that WT1 protein plays a vital role in regulating cell cycle progression and apoptosis in HER2 /neu-overexpressing breast cancer cells.
Genetic and epigenetic alterations of microRNAs and implications for human cancers and other diseases
This review focuses on the disruption of miRNAs and their key regulatory machineries by genetic alterations, with emphasis on mutations and epigenetic changes in cancer and other diseases.
Cyclooxygenase-2 Is Essential for HER2/neu to Suppress N- (4-Hydroxyphenyl)retinamide Apoptotic Effects in Breast Cancer Cells
- A. Simeone, Yu-jiang Li, L. Broemeling, Marcella M. Johnson, Musaffe Tuna, A. Tari
- Biology, MedicineCancer Research
- 15 February 2004
Apoptosis induced by the 4-HPR and COX-2 inhibitor combination, although unaffected by an anti-HER2/neu antibody, was reversed by the COx-2 product prostaglandin E2, indicating that CO X-2 is a major mechanism by which HER2/NEu suppresses 4- HPR apoptosis in breast cancer cells.
Genomic sequencing in cancer.
This review focuses on whole-genome sequencing in cancer, which can be used to provide the most comprehensive characterization of the cancer genome, the complexity of which is only beginning to understand.
Next generation sequencing and its applications in HPVassociated cancers
A review of next generation sequencing data with other omics and clinical data is crucial to better understand the pathophysiology of each individual malignancy and to select targets and to design effective personalized treatment options.
Association between Acquired Uniparental Disomy and Homozygous Mutations and HER2/ER/PR Status in Breast Cancer
It is concluded that a genome-wide scale analysis of aUPD regions for homozygous sequence alterations can provide valuable insights into breast tumorigenesis and provides statistical support using TP53 as an example that identifying aU PD regions can be an effective approach in finding aberrant genes.
Soft tissue sarcoma subtypes exhibit distinct patterns of acquired uniparental disomy
This study yields a detailed map of aUPD across 9 diverse STS subtypes and suggests the potential location of several novel tumor suppressor genes and oncogenes.