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  • Samuel K Eldersveldt, Michael A Saunderst, +6 authors Comput
Stable and efficient updates to the basis matrix factors are vital to the simplex method. The "best" updating method depends on the machine in use and how the update is implemented. For example, the classical product-form update can take advantage of the vector hardware on current supercomputers, and this helps compensate for its well-known drawbacks.(More)
IMPORTANCE Understanding the major health problems in the United States and how they are changing over time is critical for informing national health policy. OBJECTIVES To measure the burden of diseases, injuries, and leading risk factors in the United States from 1990 to 2010 and to compare these measurements with those of the 34 countries in the(More)
This survey determined the effect of the introduction of laparoscopic cholecystectomy on the rates ofcholecystectomy (total and laparoscopic) in Scotland. From 1977 to 1990, the Scottish cholecystectomy rate fell by an average ofalmost 1% per annum. With the advent of laparoscopic cholecystectomy, the total cholecystectomy rate (open and laparoscopic) rose(More)
Osteoporosis is a common complication of anorexia nervosa (AN). Although weight recovery and resumption of menses are important goals in AN treatment, they are often achieved only after a prolonged period of recovery. Therefore, it becomes important to find therapies with the potential to prevent further decreases in bone mineral density (BMD). We conducted(More)
  • João Teixeira, Carolyn Reynolds, Kevin Judd, Boris, Murray
  • 2005
Computational models based on discrete dynamical equations are a successful way of approaching the problem of predicting or forecasting the future evolution of dynamical systems. For linear and mildly nonlinear models, the solutions of the numerical algorithms in which they are based, converge to the analytic solutions of the underlying differential(More)
The herpes virus entry mediator (HVEM) receptor and its ligand, HVEM-L, are involved in both herpes simplex virus type-1 (HSV-1) herpes simplex virus type-2 (HSV-2) infection, and in T-cell activation such that antagonists of this interaction are expected to have utility in viral and inflammatory diseases. In this report we describe the configuration of a(More)
Uncertainty, incompleteness and vagueness are typical features of common-sense as well as expert knowledge. Reasoning based on such knowledge demands strategies to combine divergent information. All the more this is true in the context of integrating knowledge bases. This paper addresses knowledge representation, reasoning, and conflict management with(More)
DNA helicases are responsible for the unwinding of double-stranded DNA, facilitated by the binding and hydrolysis of 5'-nucleoside triphosphates. These enzymes represent an important class of targets for the development of novel anti-infective agents particularly because opportunity exists for synergy with existing therapies targeted at other enzymes(More)
The effects of hydrostatic pressure on the receptor-stimulated exchange of guanosine triphosphate (GTP) for guanosine diphosphate (GDP) on the a subunit of G proteins were studied in two congeneric marine teleost fishes that differ in their depths of distribution. The poorly hydrolyzable GTP analog [35S]guanosine 5'-[gamma-thio]triphosphate ([35S]GTP[S])(More)