Murray A. Freedman

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OBJECTIVE We reviewed the cases of 23 patients who were admitted to the hospital with a primary diagnosis of histopathologically confirmed necrotizing fasciitis in the lower abdomen or pelvis. Rapid demise of a healthy postpartum women piqued our interest in trying to identify the early signs and symptoms that may lead to earlier diagnosis and treatment of(More)
The overall improvement in the health of Americans over the 20th century is best exemplified by dramatic changes in 2 trends: 1) the age-adjusted death rate declined by about 74%, while 2) life expectancy increased 56%. Leading causes of death shifted from infectious to chronic diseases. In 1900, infectious respiratory diseases accounted for nearly a(More)
Approximately 4000 new cases of sudden hearing loss (SHL) occur annually in the United States, and 15,000 annually worldwide, accounting for approximately 1% of all cases of SHL. Although prevalence studies do not necessarily distinguish between idiopathic and acquired SHL, most cases of spontaneous SHL have no identifiable cause. In this article, the(More)
OBJECTIVE To determine the association between childhood-onset thrombotic thrombocytopenic purpura (TTP) and systemic lupus erythematosus (SLE). METHODS The charts of all 5 patients diagnosed with idiopathic TTP at the Hospital for Sick Children (HSC) in Toronto from 1975 to 1998, and all cases of childhood-onset TTP (ages 6-20 years) reported in the(More)
The use of estrogen or hormone replacement therapy (ERT/HRT) in preventing disease in menopausal women has been well documented. Less attention has been paid to the menopausal symptoms that can impair the quality of life of menopausal women, such as hot flushes, sleep disorders, sexual dysfunction, and alterations in mood. Researchers have used a variety of(More)
OBJECTIVE The aim of this study was to evaluate low-dose synthetic conjugated estrogens A (SCE-A) cream administered twice weekly for the treatment of moderate to severe vulvovaginal atrophy (VVA) in a symptomatic postmenopausal population. METHODS In a multicenter, double-blind, randomized, placebo-controlled study, 305 women with symptoms of VVA were(More)
The sexual response cycle in humans usually exists within the context of a partnership. Current codification of sexual function/dysfunction has failed to incorporate the concept of satisfaction and the interpersonal relationship into the cycle and both factors are crucial to most women (and the majority of older men). Partnership issues are a critical(More)
OBJECTIVES To investigate the relationship between urinary incontinence and Vitamin B12 deficiency in community-living older people using standard serum cobalamin levels as well as the metabolites methylmalonic acid (MMA) and total homocysteine (HCYS). DESIGN A prospective cross-sectional study of community-living older people. PARTICIPANTS Independent(More)