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Sequence-dependent recognition of dsDNA-binding proteins is well understood, yet sequence-specific recognition of dsRNA by proteins remains largely unknown, despite their importance in RNA maturation pathways. Adenosine deaminases that act on RNA (ADARs) recode genomic information by the site-selective deamination of adenosine. Here, we report the solution(More)
The synthesis of a novel group of quinacridine-based ligands (MMQs) is described along with an evaluation of their G-quadruplex binding properties. A set of biophysical assays was applied to characterize their interaction with DNA quadruplexes: FRET-melting experiments and equilibrium microdialysis were used to evaluate their quadruplex affinity and their(More)
In this paper, we present the main results we have obtained through our experience in designing and implementing Madeus, an authoring and presentation tool for interactive multimedia documents. This system allows an eecient support for the speciication of temporal scenarios and ts in an architecture that allows the integration of both au-thoring and(More)
A model beta-hairpin peptide has been used to investigate the context-dependent contribution of cross-strand Lys-Glu interactions to hairpin stability. We have mutated two Ser-Lys interstrand pairs to Glu-Lys salt bridges, one close to the type I' Asn-Gly turn sequence (Ser6 --> Glu), and one close to the N- and C-termini (Ser15 --> Glu). Each individual(More)
A system is said to be reactive if it interacts continuously with an environment, at a speed imposed by the environment. The system deals with inputs and outputs and the languages for programming reactive systems aim at describing the complex ordering and causality relations between the inputs and the corresponding outputs. The synchronous approach, based(More)
This report presents an extensive work on the speciication and the formal veriication of complex applications in advanced robotics systems. In a rst part, the need for such studies is presented, and a state-of-the-art in the eld is given, evolving from the computer science area to the robotics one. Then, the key features used in the paper are presented.(More)
We are interested in applications that automatically generate a dynamic multimedia presentation adapted to the needs of the user from a database of XML fragments of basic elements (video, images, paragraphs, etc.). In this paper we present an architecture which goal is to support developers of such applications. This architecture takes benefits from both(More)
This paper introduces Kaomi, a scalable toolkit for designing authoring environments of multimedia documents. The underlying concept is to provide the designer of multimedia applications with a fast method to get an authoring system based on a set of synchronized views (the presentation view for displaying the document, the scenario view for showing the(More)
The delta-conotoxin EVIA from the Conus ermineus venom, a recently characterized toxin, exhibits cis-trans isomerism of the Leu12-Pro13 bond associated with the triggering of its biological activity. In this paper we use the pseudoproline concept to target the presumed bioactive cis conformation. We report the design and the synthesis of loop 2 analogs from(More)
This paper discusses the interface needs for the emergence of new authoring tools for the creation of multimedia documents. We think that it is possible to break down the specify-and-run process of most existing tools to have more direct editing functions close to a " wysiwyg " approach. After identifying the requirements of direct editing for mul-timedia(More)