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The effect of cellular glutathione depletion on fibrinolytic activity in the arterial wall and on the levels of components of the plasma fibrinolytic system was studied in rabbits. Intraperitoneal administration of buthionine sulphoximine (4.5 mmol/kg body wt), an inhibitor of gamma-glutamyl cysteine synthetase, induced a significant reduction in liver(More)
This paper analyzes the impact and effectiveness of the Mexican Labor Retraining Program for Unemployed and Displaced Workers (PROBECAT). The strategy followed is to compare the post-training labor market experiences of trainees with those of a comparison group-a matched sample of unemployed individuals who were eligible for, but did not participate in, the(More)
The influence of dipyridamole and lysine acetylsalicylate on the incidence of atherosclerotic lesions and on arterial prostacyclin formation was studied in rabbits. Male New Zealand rabbits received i.m. for 16 months dipyridamole (12.5 mg/kg/day) and lysine acetylsalicylate (0.5 mg/kg/day). The incidence of spontaneous atherosclerotic lesions in the aorta(More)
Methods Multicentre, retrospective study based on electronic records of patients seeking care during 2005 in the regions of Aragón, Baleares and Cataluña. Principal measurements: variables related to the patient (age, sex and morbidity), the health centre (accreditation, teaching activities and localization – rural/urban centre), the physician (academic(More)
The pharmacokinetics of sulfobromophthalein was studied in the rat after depletion of hepatic glutathione levels induced by intraperitoneal administration of diethyl maleate (4.0 mmol/kg). After an intravenous bolus injection of sulphobromophthalein (120 μmol/kg) a biexponential plasma decay was found both in control and diethyl maleate pretreated rats. The(More)
The contribution of hemodynamic changes to the pathogenesis of accelerated fibrinolysis in liver disease was investigated in rats. In animals with hepatic lesions induced by a 7-week inhalation of carbon tetrachloride there was a significant increase in blood t-PA activity and PAI activity, with no significant change in portal pressure. Following a 10-min(More)
The effect of intraperitoneal administration of diethyl maleate on biliary excretion and choleretic action of sulfobromophthalein (BSP) was investigated in rats. Diethyl maleate was injected 60 min prior to the administration of the dye to avoid interferences with the organic anion transport system. The glutathione content of the liver was decreased by 75%(More)
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