Murat Kekilli

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AIM Acute pancreatitis (AP) constitutes a systemic inflammatory process which is often accompanied by thrombosis and bleeding disorders. The role of platelets in the pathophysiology of the disease has not been elucidated yet. Mean platelet volume (MPV) is an index of platelet activation and reported to be influenced by inflammation. The objective of the(More)
BACKGROUND Despite advances in the understanding of the pathophysiological basis of autoimmune hepatitis (AIH), it is still difficult to delineate the mechanisms involved in progression from hepatic inflammation toward fibrosis. Our aim was to study serum concentrations of NO in AIH of different histological severity and possible effects of(More)
Dear Editor We have read with great interest the promising article by Efe et al. [1] recently published in your journal. The authors successfully demonstrated the role of Vitamin D in the hepatic fibrotic process and severe inflammation in patients with autoimmune hepatitis (AIH). Moreover, they stated that Vitamin D might be a potential biomarker for(More)
BACKGROUND/AIMS Differentiation of benign obstructive jaundice from malignant obstructive jaundice still remains difficult, despite improvements in diagnostic modalities. The aim of this study is to evaluate the usefulness of red cell distribution width (RDW) in differentiating benign and malignant causes of obstructive jaundice. METHODOLOGY One hundred(More)
Gastrointestinal (GI) bleeding refers to any hemorrhage ascribed to the pathologies of the gastrointestinal tract, extending from the mouth to the anal canal. Despite the recent improvements in the endoscopic, hemostatic and adjuvant pharmacologic techniques, the reported mortality is still around 5%-10% for peptic ulcer bleeding and about 15%-20% for(More)
Procoagulant state, inflammation, and endothelial dysfunction have been documented in metabolic syndrome. Endothelial dysfunction is a strong predictor of cardiovascular events. Studies on the association of thrombin-activatable fibrinolysis inhibitor and thrombosis are still controversial, but substantial evidence suggests that increased(More)
Hepatitis B and C virus (HBV and HCV) infection have been proposed as risk factors for cholangiocarcinoma, but the results are inconsistent through different reports. This study is to carry out a hospital-based case-control study to investigate the association between HBV and HCV infection and cholangiocarcinoma in Turkey. A total of 127 cases and 48(More)