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PURPOSE To investigate the association between Apolipoprotein E (APOE), tumor suppressor protein p53 (p53), and cyclin-dependent kinase inhibitor 1A (p21) genes and primary open-angle glaucoma (POAG) in a cohort of Turkish subjects. METHODS Seventy-five POAG patients (49 women, 26 men) and 119 healthy subjects (67 women, 52 men) were genotyped with(More)
In this article we review the mechanism of ocular surface staining. Water-soluble dyes are excluded from the normal epithelium by tight junctions, the plasma membranes and the surface glycocalyx. Shed cells can take up dye. A proportion of normal corneas show sparse, scattered time-dependent, punctate fluorescein uptake, which, we hypothesise, is due to a(More)
Dry eye disease (DED) is a distressing ocular condition. Due to its multifactorial nature, clinical and biological signs of DED can be inconsistent and sometimes discordant with symptomatology. Consequently, no gold-standard model for determining DED severity exists. This can impact treatment decisions and complicate evaluation of disease progression,(More)
PURPOSE To compare the retinal nerve fiber layer [RNFL] thickness of the amblyopic eye with that of the normal eye in patients with anisometropic and strabismic amblyopia. METHODS Scanning laser polarimetry was performed with the GDx Nerve Fiber Analyzer (NFA), a scanning laser ophthalmoscope that measures the thickness of the peripapillary RNFL(More)
We present the brain MR imaging findings in a 13-month-old male infant with intracranial extracerebral brain tissue demonstrating the typical laminar organization pattern of fetal cerebral wall accompanied by unilateral anophthalmia and ethmoidal encephalocele supported by CT imaging.
PURPOSE To evaluate the relationship between global indices of Humphrey standard automated perimetry (SAP, 30-2 SITA standard test), Humphrey Matrix frequency doubling technology (FDT, 30-2 threshold test), and Heidelberg Retina Tomograph (HRT II) parameters and measure the level of agreement among these 3 tests in classifying eyes as normal or abnormal. (More)
PURPOSE To investigate the association of lysyl oxidase like 1 (LOXL1) variants with exfoliation syndrome (XFS), exfoliation glaucoma (XFG), and primary open angle glaucoma (POAG) in a Turkish population. METHODS Two LOXL1 single nucleotide polymorphisms (SNPs), rs1048661 (R141L) and rs3825942 (G153D), were analyzed in 300 Turkish patients (100 patients(More)
PURPOSE To evaluate the corneal characteristics of patients with epithelial basement membrane dystrophy (EBMD) using an in vivo laser confocal microscope, Heidelberg Retina Tomograph II, Rostock Cornea Module (HRT II RCM). METHODS Sixteen women and 13 men who were diagnosed with or suspected to have EBMD were included in the study. The mean age of the(More)
OBJECTIVE To evaluate the effect of visible optic nerve head drusen (ONHD) on retinal nerve fiber layer (RNFL) thickness retardation by using scanning laser polarimetry. METHODS Twenty-three eyes of 13 patients with visible ONHD and 26 eyes of 13 age- and sex-matched control subjects were involved in the study. Ophthalmologic examination, scanning laser(More)
In this paper, we report two cases of a 62-year-old patient presented with blurred vision and a 45-year-old male diagnosed with multiple myeloma who was referred from the Department of Oncology. Slit-lamp examination, in vivo confocal microscopy (IVCM), systemic work-up and serum protein electrophoresis were obtained. In both patients, slit-lamp findings(More)