Munther Alqaisi

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Adequate immunosuppression remains a major obstacle to successful xenotransplantation, with early xenograft rejection appearing to be mediated by humoral factors. Total-lymphoid irradiation (TLI) and 15-deoxyspergualin (DOSP) have been shown to be effective immunosuppressive agents in allografs. In this study, TLI alone and in combination with DOSP and(More)
OBJECTIVES We conducted a prospective phase I trial to determine the maximum tolerated dose of capecitabine and irinotecan when used in combination with celecoxib and radiation as preoperative therapy for patients with locally advanced rectal cancer. METHODS Patients with histologic diagnosis of adenocarcinoma of distal rectum, evidence of T3/T4 tumor or(More)
The effectiveness of fractionated TLI in promoting allograft tolerance without chronic drug therapy is well established experimentally. TLI has not been widely applied in clinical transplantation, largely due to logistic and medical limitations of pretransplant TLI conditioning. Potential use of posttransplant TLI (PT-TLI) has not been critically evaluated.(More)
A study of 813 men and 187 women who underwent internal mammary artery (IMA) bypass from 1976 to the present time is presented. In approximately 10% of patients, only the IMA was used for coronary artery bypass, and in approximately 90%, one to four saphenous vein grafts were used additionally. Hospital mortality in the series was 1.8%. The IMA, when(More)
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