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A series of isonicotinic acid hydrazide derivatives (1–19) was synthesized and tested in vitro for antimycobacterial activity against Mycobacterium tuberculosis and antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Candida albicans, and Aspergillus niger and the results indicated that the compounds with OH, SCH3, and(More)
The resurgence of tuberculosis and emergence of multidrug resistant isolates has focused attention on the need for an improved understanding of molecular aspects of the disease, and for elucidation of the factors responsible for drug action and resistance. Isoniazid is the frontline drug employed in the treatment of tuberculosis. Recent research has probed(More)
A series of isonicotinic acid-1-(substituted phenyl)-ethylidene/cycloheptylidene hydrazide derivatives (1–12) was tested for their, in vitro antimycobacterial activity against Mycobacterium tuberculosis, and compound 2 was found to be more active than isoniazid. The antiviral screening results indicated that none of the tested compounds was active against a(More)
A series of isoxazolyl thiazolyl pyrazoles 5a–d was synthesized by multi-step process, starting from 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one (dehydroacetic acid, DHAA) 1. DHAA 1 was easily converted to thiosemicarbazone 2 which on reaction with α-bromoketones yielded thiazolyl hydrazones 3. Refluxing 3 in ethanol-acetic acid furnished(More)
Thiol functionalization of psyllium was carried out to enhance its mucoadhesive potential. Thiolation of psyllium was achieved by esterification with thioglycolic acid. Thiolation was observed to change the surface morphology of psyllium from fibrous to granular and result in a slight increase in the crystallinity and swelling. Thiolated psyllium was found(More)
The present study was attempted to predict the antimycobacterial activity of 4-(5-substituted-1,3,4-oxadiazol-2-yl)pyridines. The QSAR studies revealed that topological molecular descriptors best described the antimycobacterial activity of 4-(5-substituted-1,3,4-oxadiazol-2-yl)pyridines. The mt-QSAR models depicted that valence first order molecular(More)
The objective of present study was to prepare composite microbeads of psyllium arabinoxylan and sodium alginate by ionotropic gelation method using calcium chloride as a cross linker and was further evaluated for release study. The effect of concentration of sodium alginate/arabinoxylan and concentration of calcium chloride on the entrapment efficiency and(More)
Aqueous solutions of carboxymethyl gum kondagogu (CMGK), an anionic bioadhesive polymer were evaluated as vehicles for ophthalmic delivery using tropicamide as a model drug. Aqueous ophthalmic solution of tropicamide (1 %, w/v) in CMGK (5 %, w/v) dispersions were formulated. The aqueous CMGK vehicle, formulated tropicamide eye drops and commercial(More)
Gum ghatti is a high molecular weight anionic polysaccharide used in food and pharmaceutically applied as binder, thickener, emulsifier and sustained release matrix as promising polysaccharide which has not been explored as mucoadhesive polymer. The present study was carried out to evaluate gum ghatti as mucoadhesive polymer by preparing buccal disc using(More)
Plan: A review on the importance of pyrazinamide derivatives for the treatment of tuberculosis Prologue: Tuberculosis is a chronic granulomatous disease and a major health problem in developing countries. Pyrazinamide (PZA) is an important front-line drug for the treatment of tuberculosis (TB). Pyrazinamide, along with isoniazid and rifampicin, forms the(More)
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