Munira Borhany

Learn More
Deficiency of coagulation factor XIII (FXIII) belongs to the rare bleeding disorders and its incidence is higher in populations with consanguineous marriages. The aims of this study were to characterize patients and relatives from seven families with suspected FXIII deficiency from Pakistan and to identify the underlying mutations. As a first indicator of(More)
OBJECTIVE To determine the frequency and clinical features of bleeding disorders in the tribe as a result of consanguineous marriages. DESIGN Cross Sectional Study INTRODUCTION Countries in which consanguinity is a normal practice, these rare autosomal recessive disorders run in close families and tribes. Here we describe a family, living in village Ali(More)
Glanzmann thrombasthenia (GT) is an inherited genetic disorder affecting platelets, which is characterized by spontaneous mucocutaneous bleeding and abnormally prolonged bleeding in response to injury or trauma. The underlying defect is failure of platelet aggregation due to qualitative and/or quantitative deficiency of platelet integrin αIIbβ3 resulting(More)
Fibrinogen is a plasma glycoprotein mainly synthesised by hepatocytes and circulating as a 340-kDa hexamer consisting of two sets of three different polypeptide chains (Aα, Bβ, and γ, encoded by the FGA, FGB, and FGG gene, respectively). Congenital afibrinogenaemia and hypofibrinogenaemia are rare bleeding disorders characterised by abnormally low levels of(More)
The aim of the study was to assess the prevalence of HCV, HBV, and HIV infections among the patients with hemophilia. Patients with Hemophilia A and B were evaluated who visited hospital for factor replacement therapy. The viral markers tested in these patients included anti-HCV-Ab, HBsAg, and anti-HIV-Ab. Seroprevalence was compared from 5717 exchange(More)
OBJECTIVE To determine the frequency of inherited bleeding disorders, its complications, and treatment modalities available for its treatment. DESIGN Cross-sectional study. PATIENTS AND METHODS Patients with a history of bleeding tendency were tested for confirmation of the diagnosis. History and clinical findings were recorded. Laboratory analysis(More)
This study was conducted on patients with a history of congenital bleeding disorders or with suspected bleeding tendencies. Laboratory analysis revealed Von Willebrand disease (VWD) in 68 (21.3%) of 318 participants with male to female ratio of 0.8: 1 (31 to 37) and median age 17 years (range 2-45 years). Type 3 being the most frequent, 35 (51.4%) of 68,(More)
OBJECTIVE The aim of the study was to determine the frequency and reasons for donor deferral prior to the blood donation process in our population. BACKGROUND Transfusion is an irreversible event that carries potential risks as well as benefits to the recipient. Therefore, donor selection prior to blood donation is one of the most important steps in(More)
National Institute of Blood Disease and Bone Marrow Transplantation Karachi, Pakistan *Corresponding Author’s Email: Tel.: +923009370577 A retrospective analysis of 5 years data of myeloproliferative neoplasm (MPN) other than chronic myeloid leukaemia (CML) was done. All the cases were diagnosed and classified according to World(More)