Munir Iqbal Malik

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To assess the utility of various indicators of biotin status, marginal biotin deficiency was induced experimentally in normal adults. Ten subjects consumed a diet that contained enough avidin to bind seven times more biotin than that in the diet. Blood and 24-h urine samples were collected before the diet began and twice weekly thereafter for 20 d. The(More)
Estimates of the plasma concentration of biotin differ considerably. Variation in detectability of biotin bound covalently to protein is one potential source of disagreement. In this study we determined the amount of biotin covalently bound to plasma protein. First, greater than 99% of free and reversibly bound biotin was removed by dialysis; then greater(More)
Recent studies have demonstrated a strong association between type II (immunologically mediated) heparin-induced thrombocytopenia/thrombosis (HITP) and antibodies reactive with complexes consisting of heparin and platelet factor 4 (PF4), a heparin-binding protein normally found in platelet-alpha granules. However, the frequency with which such antibodies(More)
Recent reports indicate that antibodies associated with heparin-induced thrombocytopenia and thrombosis (HITP) are specific for complexes formed between heparin and the heparin-binding, platelet alpha granule protein, platelet factor 4 (PF4). As with other disorders mediated by immune complexes (IC), the characteristics of the involved immunoglobulins could(More)
OBJECTIVE To observe and compare the Tympanic Temperature (TT) readings with the Oral Mercury Thermometer (OMT) in an OPD setting. STUDY DESIGN Observational comparative study. PLACE AND DURATION OF STUDY The Outpatient Department, Shifa International Hospital, Islamabad, from June to September 2008. METHODOLOGY By consecutive sampling, 2000 OPD(More)
The reduced variability of the sinus rhythm is an adverse prognostic factor in patients after acute myocardial infarction. The paper is a review focused on the heart rate variability and its clinical correlate. The authors mention non-cardiological areas where assessment of heart rate variability is done as a matter of convention or experimentally. Methods(More)
A 14-year-old boy was referred for evaluation of a cervical esophageal "stricture" diagnosed by upper gastrointestinal radiograph, which had been performed for evaluation of dysphagia and dysphonia of several months' duration. Neurological examination revealed several cranial nerve abnormalities and hyperreflexia, raising the suspicion of a cervicomedullary(More)
Objective To determine the neurodevelopmental outcomes, functional limitations and medical conditions associated with very low birth weight and extremely low birth weight infants. Subjects and Methods The neonatal intensive care unit (NICU) admission and outpatient clinic follow up records of all newborns, treated at Shifa International Hospital from(More)