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BACKGROUND AND OBJECTIVE To assess the early therapeutic response after switching from multiple injections of bevacizumab or ranibizumab to aflibercept in eyes with neovascular age-related macular degeneration (AMD). PATIENTS AND METHODS SD-OCT scans of patients with neovascular AMD that was suboptimally responsive to multiple injections of bevacizumab or(More)
PURPOSE To explore the correlation between outer retinal substructures and visual acuity in dry age-related macular degeneration (AMD). METHODS Analysis of spectral domain optical coherence tomography datasets from 100 eyes of 100 consecutive patients with dry AMD was performed. The internal limiting membrane, outer nuclear layer (ONL), external limiting(More)
PURPOSE To compare the measurements of drusen area from manual segmentation of color fundus photographs with those generated by an automated algorithm designed to detect elevations of the retinal pigment epithelium (RPE) on spectral domain optical coherence tomography (SD-OCT) images. METHODS Fifty eyes with drusen secondary to nonexudative age-related(More)
PURPOSE To investigate the reproducibility of anterior segment angle (ACA) metrics measurements in normal subjects on Cirrus spectral domain optical coherence tomography (SD-OCT). METHODS 40 eyes from 20 healthy, normal subjects underwent anterior segment imaging using a Cirrus SD-OCT. For each eye, 2 acquisitions of 5-line raster scans were performed(More)
A case of X-linked retinoschisis with anatomic and functional issues correlated by a constellation of methods, including spectral-domain optical coherence tomography, microperimeter, electroretinography, and multifocal electroretinography, is described. This case highlights the importance of microperimetry in the presence of normal or subtle abnormalities(More)
PURPOSE To determine the prognostic value of outer retinal tubulation (ORT) in the enlargement amount of geographic atrophy (GA) in eyes with age-related macular degeneration (AMD). DESIGN Cohort study. PARTICIPANTS One hundred eight fellow untreated eyes of 143 patients with GA resulting from AMD enrolled in the MAHALO study (clinicaltrials.gov(More)
BACKGROUND Diabetic retinopathy (DR)-a common complication of diabetes-is the leading cause of vision loss among the working-age population in the western world. DR is largely asymptomatic, but if detected at early stages the progression to vision loss can be significantly slowed. With the increasing diabetic population there is an urgent need for automated(More)
PURPOSE To assess the personal and demographic risk factors for proliferative diabetic retinopathy in Latino Americans in Los Angeles County. METHODS In this prospective, non-interventional, cross-sectional case control study, seven hundred and twenty-nine subjects from Los Angeles County University of Southern California Medical Center (LAC + USC), Los(More)
PURPOSE To evaluate the accuracy and reproducibility of drusen quantification by an automated drusen segmentation algorithm in spectral domain optical coherence tomography (SD-OCT) images of eyes with non-neovascular age-related macular degeneration (AMD). METHODS Drusen segmentation was performed using both a commercial automated algorithm (Cirrus OCT(More)
PURPOSE To evaluate the retinal sensitivity and fixation characteristics in participants with diabetes mellitus, using the microperimeter (MP-1) and to correlate the MP-1 values with the severity of diabetic retinopathy (DR). METHODS We performed complete ophthalmic examinations, including best-corrected visual acuity, slit-lamp examination, indirect(More)