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Three 8-week growth experiments were conducted to quantify the requirements of the fingerling Cirrhinus mrigala for the dietary branched-chain amino acids valine (experiment 1), isoleucine (experiment 2) and leucine (experiment 3). Six isonitrogenous (400 g/kg) and isoenergetic (17.90 kJ/g) test diets were formulated with a gradation of 2.5 g/kg for each(More)
An 8-week growth trial was conducted to assess the effect of dietary protein on growth, feed utilization, protein retention efficiency, and body composition of young Heteropneustes fossilis (10.02 +/- 0.09 g; 9.93 +/- 0.07 cm). Isocaloric (4.15 kcal g(-1), GE) diets with varying levels of protein (25, 30, 35, 40, 45, and 50% of the diet) were fed near to(More)
In order to determine the dietary isoleucine requirement of fingerling catla, Catla catla (4.25 ± 0.15 cm, 0.61 ± 0.04 g), six isonitrogenous (33.0 % crude protein) and isocaloric (13.7 kJ/g digestible energy) amino acid test diets containing casein, gelatin and l-crystalline amino acids with graded levels of isoleucine (0.5, 0.75, 1.0, 1.25, 1.5 and 1.75 %(More)
Nanoparticles (NP) are solid colloidal particles ranging in size from 1 to 1000 nm that are utilized as drug delivery agents. The use of NPs to deliver drugs to the brain across the blood-brain barrier (BBB) may provide a significant advantage to current strategies. The primary advantage of NP carrier technology is that NPs mask the blood-brain barrier(More)
Morpholinoalkyl esters (HCl salts) of diclofenac (1) were synthesized and evaluated in vitro and in vivo for their potential use as prodrugs for oral delivery. Prodrugs were freely soluble in simulated gastric fluid (SGF) and pH 7.4 phosphate buffer and showed a minimum of a 2000-fold increase in solubility over the parent drug. All prodrugs were more(More)
Conventional taste-masking strategies are used to overcome the bitter taste perception of pharmaceuticals by coating the drug particles and/or adding flavoring agents. However, for certain product categories such as rapid dissolve sublingual tablets, taste-masking is challenging. Programs exploring such formulation strategies in the LO-CS phase or post CS(More)
Morpholinoalkyl esters (HCl salts) of naproxen 1 and indomethacin 3 were synthesized and evaluated in vitro and in vivo for their potential use as prodrugs for oral delivery. Prodrugs were freely soluble in simulated gastric fluid (SGF) and pH 7.4 phosphate buffer and showed a minimum of a 2000-fold increase in solubility over the parent drugs. All prodrugs(More)
Physicochemical and nutritional quality of five improved cultivars of desi and kabuli chickpeas and their products were studied. The kabuli chickpea had larger seed (26 g/100 seeds) than desi type (21 g/100 seeds). The hydration capacity per seed of desi (0.16 g) was lower than kabuli type (0.26 g). A positive correlation (r = 0.87) between seed weight and(More)
A 12-week experiment was conducted to quantify dietary lysine requirement of fingerling Catla catla (3.65 ± 0.05 cm; 0.58 ± 0.02 g) by feeding casein–gelatine-based diets (33.0 % crude protein; 14.3 kJ/g digestible energy) with six levels of l-lysine (1.25, 1.50, 1.75, 2.00, 2.25 and 2.50 % dry diet). The experiment was conducted in eighteen 70-L indoor(More)
Ibuprofen:Eudragit coprecipitates were prepared in 10:3 ratios and their physical properties and related dissolution characteristics were determined. The Eudragit polymers used for the studies were three anionics (Eudragit L100, Eudragit L100-55, and Eudragit S-100), one anionic:cationic mixture used in a 1:1 ratio (Eudragit S100 + E100), and four(More)