Mukesh Maheshwari

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Oxidative damage and amyloid-β (Aβ) protein misfolding are prominent features of Alzheimer's disease (AD). In vitro studies indicated a direct linkage between these two features, where lipid oxidation products augmented Aβ misfolding. We tested this linkage further, mimicking specific conditions present in amyloid plaques. In vitro lipid oxidation and lipid(More)
Reducing power consumption without sacrificing processing speed is a critical factor in VLSI design, especially for hand-held devices. In CMOS circuits, dynamic power consumption is proportional to the transition frequency, capacitance, and square of supply voltage. Consequentially, reducing supply voltage provides significant power savings at the expense(More)
The ever increasing growth in laptop and portable systems in cellular networks has intensified the research efforts in low power microelectronics. Now a day, there are many portable applications requiring low power and high throughput than ever before. Thus, low power system design has become a significant performance goal. So this paper is face with more(More)
Lipid oxidative damage and amyloid β (Aβ) misfolding contribute to Alzheimer's disease (AD) pathology. Thus, the prevention of oxidative damage and Aβ misfolding are attractive targets for drug discovery. At present, no AD drugs approved by the Food and Drug Administration (FDA) prevent or halt disease progression. Hydralazine, a smooth muscle relaxant, is(More)
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