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The greater reactivity of estradiol-3,4-quinone vs estradiol-2,3-quinone with DNA in the formation of depurinating adducts: implications for tumor-initiating activity.
- Muhammad Zahid, E. Kohli, M. Saeed, E. Rogan, E. Cavalieri
- Chemistry, BiologyChemical research in toxicology
The relative reactivities of E2-3,4-Q and E-2-2,3-Q to form depurinating adducts correlate with the carcinogenicity, mutagenicity, and cell-transforming activity of their precursors, the catechol estrogens 4-OHE2 and 2- OHE2.
Resveratrol Prevents Estrogen-DNA Adduct Formation and Neoplastic Transformation in MCF-10F Cells
- Fang Lu, Muhammad Zahid, Cheng Wang, M. Saeed, E. Cavalieri, E. Rogan
- Biology, ChemistryCancer Prevention Research
- 1 July 2008
Resveratrol can prevent breast cancer initiation by blocking multiple sites in the estrogen genotoxicity pathway.
Reduced formation of depurinating estrogen-DNA adducts by sulforaphane or KEAP1 disruption in human mammary epithelial MCF-10A cells.
Treatment with SFN or siKEAP1 has similar effects on reduction of depurinating estrogen-DNA adduct levels following estrogen challenge, however, these pharmacologic and genetic approaches have different effects on estrogen metabolism to O-methyl and glutathione conjugates.
Estrogen metabolism and formation of estrogen-DNA adducts in estradiol-treated MCF-10F cells The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin induction and catechol-O-methyltransferase inhibition
Cytochrome P450 isoforms catalyze formation of catechol estrogen quinones that react with DNA.
Ultraviolet A light induces DNA damage and estrogen-DNA adducts in Fuchs endothelial corneal dystrophy causing females to be more affected
- Cailing Liu, Taiga Miyajima, U. Jurkunas
- Biology, MedicineProceedings of the National Academy of Sciences
- 18 December 2019
A nongenetic FECD animal model is established based on the physiologic outcome of CE susceptibility to oxidative stress by demonstrating that corneal exposure to ultraviolet A (UVA) recapitulates the morphological and molecular changes of FECD.
Unbalanced estrogen metabolism in ovarian cancer
- Muhammad Zahid, C. Beseler, J. Hall, T. LeVan, E. Cavalieri, E. Rogan
- Biology, ChemistryInternational journal of cancer
- 15 May 2014
The findings indicate that estrogen metabolism is unbalanced in ovarian cancer and suggest that formation of estrogen–DNA adducts plays a critical role in the initiation of ovarian cancer.
Association of the CYP1B1*3 allele with survival in patients with prostate cancer receiving docetaxel
Evidence is provided that CYP1B1*3 may be an important marker for estimating docetaxel efficacy in patients with prostate cancer and an indirect gene-drug interaction was interfering with the primary mechanism of action of docetAXel, tubulin polymerization.
Suggestive evidence for the induction of colonic aberrant crypts in mice fed sodium nitrite
The view that NaNO2 may be a risk factor for colon carcinogenesis is supported.
Inhibition of depurinating estrogen-DNA adduct formation by natural compounds.
- Muhammad Zahid, N. Gaikwad, E. Rogan, E. Cavalieri
- Biology, ChemistryChemical research in toxicology
- 27 November 2007
It is demonstrated that all four selected compounds can inhibit the formation of depurinating estrogen-DNA adducts and set the stage for studies of their ability to inhibit adduct formation and malignant transformation in mammary epithelial cells.