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Phosphoryloxymethyl carbonates and carbamates of the type R1R2X-CO-O-CH2-O-PO3−2 (X = O or N) were evaluated as potentially novel water-soluble collapsible prodrugs for alcohols and amines. These… (More)
The kinetics and mechanism of the degradation of cyclosporin A have been studied under aqueous acidic conditions. The rate of degradation was found to be specific acid-catalyzed over the pH range… (More)
Abstract A variety of analytical techniques were used to elucidate the kinetics, reaction pathway and mechanism of hydrolysis of O 6 -benzylguanine, an O 6 -alkylguanine-DNA alkyltransferase… (More)
Communicated compositions designed for delayed release rasagiline (rasagiline) while maintaining specific pharmacokinetic properties.
Abstract Modified amino acids and peptides are in the focus of medicinal chemistry as potential mimics of natural compounds that may act as inhibitors and modulators of natural processes. Along with… (More)
Der beskrives formuleringer af rasagilinbase der er designet til at forsinke frigi- velsen af rasagilin og samtidig opretholde specifikke farmakokinetiske egen- skaber. Ligeledes beskrevet er… (More)