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OBJECTIVES Poor adherence is one of the biggest obstacles in therapeutic control of high blood pressure. The objectives of this study were (i) to measure adherence to antihypertensive therapy in a representative sample of the hypertensive Pakistani population and (ii) to investigate the factors associated with adherence in the studied population. METHODS(More)
Heavy metals were analyzed in different foods crops, milk, meat and blood samples collected from different age group subjects such as children (1-12 years), adolescent (12-18 years), adults (18-45 years) and old age (above 45 and 55 years for males and females, respectively) from polluted and relatively less polluted areas. The results revealed that the(More)
BACKGROUND AND AIM Pakistani people belong to an ethnic group which has the highest rate of coronary artery disease (CAD). We investigated the possible correlation between deficiency of vitamins B6, B12 or folic acid and hyperhomocysteinemia in Pakistani patients with acute myocardial infarction (AMI). A case-control study was carried out involving 224 AMI(More)
BACKGROUND Control of blood pressure (BP) remains suboptimal worldwide. The objective of this study was to determine whether (primary) general practitioners' (GPs) approach to high BP is in accordance with international guidelines. METHODS AND RESULTS We conducted a cross-sectional survey of 1000 randomly selected GPs from urban areas in Pakistan during(More)
Food crops irrigated with wastewater are mostly contaminated with heavy metals and considered as a main pathway for human exposure. In this study, soil and food crops samples were collected from wastewater irrigated soils, background and relatively less polluted areas. Results of the sequential extraction and total metals concentrations in soils indicated(More)
Haptoglobin (Hp) phenotypes were studied in 72 oesophageal and 104 gastric cancer patients and compared with 100 healthy controls to see if there is any association between oesophageal and gastric cancer and haptoglobin type. There was a significantly increased frequency of Hp 2-1 (59.7%) and Hp 2-2 (91.3%) in oesophageal and gastric cancer patients. Our(More)
BACKGROUND Gambogic acid is a potent anticancer agent and has been found effective against various types of cancer cells. The present study was addressed to explore the cytotoxic potential of Gambogic acid and the modulation of autophagy and apoptosis in bladder cancer cells T24 and UMUC3. METHODS Bladder cancer cell lines T24 and UMUC3 were treated with(More)
Obesity and hypertension are two major inter-related cardiovascular risk factors. Decrease in adiposity is one of the most effective preventive measures not only in decreasing the overall cardiovascular risk but also the blood pressure. This cross-sectional study measured the effect of various measures of adiposity on blood pressure in normal healthy(More)
Multiple genetic variants have been reliably associated with obesity-related traits in Europeans, but little is known about their associations and interactions with lifestyle factors in South Asians. In 16,157 Pakistani adults (8232 controls; 7925 diagnosed with myocardial infarction [MI]) enrolled in the PROMIS Study, we tested whether: a) BMI-associated(More)
OBJECTIVE To determine the incidence of Coronary Artery Ectasia (CAE) at our teaching hospital to describe the patients and angiographic characteristics. METHODS A retrospective analysis was conducted on all coronary angiograms performed at the catheterization laboratory of Karachi Institute of Heart Diseases, a tertiary care center, between the period of(More)