Muhammad Babur

Learn More
Intratumoural hypoxia (low oxygen tension) is associated with aggressive disease and poor prognosis. Hypoxia-inducible factor-1 is a transcription factor activated by hypoxia that regulates the expression of genes that promote tumour cell survival, progression, metastasis, and resistance to chemo/radiotherapy. In addition to hypoxia, HIF-1 can be activated(More)
Complications associated with the development of lung metastases have a detrimental effect on the overall survival rate of many cancer patients. Preclinical models that mimic the clinical aspects of lung metastases are an important tool in developing new therapy options for these patients. The commonly used intravenous models only recapitulate dissemination(More)
Therapeutic inhibition of poly(ADP-ribose) polymerase (PARP), as monotherapy or to supplement the potencies of other agents, is a promising strategy in cancer treatment. We previously reported that the first PARP inhibitor to enter clinical trial, rucaparib (AG014699), induced vasodilation in vivo in xenografts, potentiating response to temozolomide. We now(More)
GCMs were selected based on vintage, resolution, validity and representativeness of results. The combination of GCMs can be used even though the selected GCMs may not necessarily be the best models for the area [1]. Performance Parameters Mostly the following statistical parameters are used for the comparison of data from two or more different sources [2].(More)
BACKGROUND Small cell lung cancer (SCLC) is an extremely aggressive disease, commonly displaying therapy-resistant relapse. We have previously identified neuroendocrine and epithelial phenotypes in SCLC tumours and the neuroendocrine marker, pro-opiomelanocortin (POMC), correlated with worse overall survival in patients. However, the effect of treatment on(More)
Assessment of climate change on reservoir inflow is important for water and power stressed countries. Projected climate is subject to uncertainties related to climate change scenarios and Global Circulation Models (GCMs). This paper discusses the consequences of climate change on discharge. Historical climatic and gauging data were collected from different(More)
Aim There is need for non-invasive methods to identify, quantify and map tumour hypoxia. In this study we used an emerging technology – R 1 oxygen enhanced MRI (OE-MRI) – to distinguish those tumour sub-regions that respond to hyperoxic gas challenge from refractory sub-regions. We hypothesised that the proportion of refrac-tory tumour tissue (Oxy-R) would(More)
  • 1