Muhammad Azizul Hakim

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Human corneal equivalents comprising the three main layers of the cornea (epithelium, stroma, and endothelium) were constructed. Each cellular layer was fabricated from immortalized human corneal cells that were screened for use on the basis of morphological, biochemical, and electrophysiological similarity to their natural counterparts. The resulting(More)
Collagen hydrogel matrices with high optical clarity have been developed from collagen I, cross-linked with a copolymer based on N-isopropylacrylamide, acrylic acid and acryloxysuccinimide. The controlled reaction of collagen amine groups with this copolymer under neutral pH and aqueous conditions gave robust, optically clear hydrogels and prevented the(More)
Stabilized collagen-glycosaminoglycan scaffolds for tissue engineered human corneas were characterized. Hydrated matrices were constructed by blending type I collagen with chondroitin sulphates (CS), with glutaraldehyde crosslinking. A corneal keratocyte cell line was added to the scaffolds with or without corneal epithelial and endothelial cells.(More)
Software emulation has been proven useful in many scenarios, such as software testing, malware analysis, and intrusion response. However, fine-grained software emulation (e.g., at the instruction level) incurs considerable execution overhead (about 8x performance degradation), which hampers its use in production settings. In this paper, we propose MOSE(More)
Macros provide one potential avenue for research into learning for planning. Most existing macro-learning methods acquire only macros that are observable from given example plans. This means they cannot learn other macros that are not observable from their training examples. A randomly selected collection of examples might not encompass many useful macros.(More)
The hippocampal area Cornu Ammonis (CA) CA2 is important for social interaction and is innervated by Substance P (SP)-expressing supramammillary (SuM) nucleus neurons. SP exerts neuromodulatory effects on pain processing and central synaptic transmission. Here we provide evidence that SP can induce a slowly developing NMDA receptor- and protein(More)
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