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Mapping of chromosomal regions harboring genetic polymorphisms that regulate complex traits is usually followed by a search for the causative mutations underlying the observed effects. This is often a challenging task even after fine mapping, as millions of base pairs including many genes will typically need to be investigated. Thus to trace the causative(More)
BACKGROUND Non-synonymous single-nucleotide polymorphisms (nsSNPs) within the coding regions of genes causing amino acid substitutions (AASs) may have a large impact on protein function. The possibilities to identify nsSNPs across genomes have increased notably with the advent of next-generation sequencing technologies. Thus, there is a strong need for(More)
A systematic approach to the inventory control and classification may have a significant influence on company competitiveness. In practice, all inventories cannot be controlled with equal attention. To efficiently control the inventory items and to determine the suitable ordering policies for them, multi-criteria inventory classification is used. The(More)
BACKGROUND Medicines are a main therapeutic intervention provided within hospitals and their proper use in the outpatient setting is important for patients and the community. The objective of this study was to evaluate drug use patterns in the outpatient departments (OPDs) of two tertiary care hospitals (Bahawal Victoria Hospital and Civil Hospital) in the(More)
The hardware technology characterized by the device parameters (DPs) often drives the architectural optimization in a novel computer design such as the quantum computer. We highlight the role of DPs by quantifying the performance of a fully error-corrected 1024-bit quantum carry look-ahead adder on a modular, reconfigurable architecture based on trapped(More)
Efforts to build quantum computers using ion-traps have demonstrated all elementary qubit operations necessary for scalable implementation. Modular architectures have been proposed to construct modest size quantum computers with up to 10<sup>4</sup> - 10<sup>6</sup> qubits using technologies that are available today (MUSIQC architecture). Concrete(More)
The optimal design of a fault-tolerant quantum computer involves finding an appropriate balance between the burden of large-scale integration of noisy components and the load of improving the reliability of hardware technology. This balance can be evaluated by quantitatively modeling the execution of quantum logic operations on a realistic quantum hardware(More)
Background. It has recently been reported that hepatitis B (HBV) reactivation often occurs after the use of rituximab and stem cell transplantation in patients with lymphoma who are hepatitis B surface antigen (HBsAg) negative. However, clinical data on HBV reactivation in multiple myeloma (MM) is limited to only a few reported cases. Bortezomib and(More)