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OBJECTIVE Our goal was to determine the impact of the initiation of inappropriate antimicrobial therapy on survival to hospital discharge of patients with septic shock. METHODS The appropriateness of initial antimicrobial therapy, the clinical infection site, and relevant pathogens were retrospectively determined for 5,715 patients with septic shock in(More)
Background. It has recently been reported that hepatitis B (HBV) reactivation often occurs after the use of rituximab and stem cell transplantation in patients with lymphoma who are hepatitis B surface antigen (HBsAg) negative. However, clinical data on HBV reactivation in multiple myeloma (MM) is limited to only a few reported cases. Bortezomib and(More)
Iron deficiency limits the efficacy of recombinant human erythropoietin (rhEPO) therapy in end-stage renal disease (ESRD) patients. Functional iron deficiency occurs with serum ferritin >500 ng/ml and/or transferrin saturation (TSAT) of 20 to 30%. This study examines the effects of a maintenance intravenous iron dextran (ivID) protocol that increased TSAT(More)
Mesenchymal stem cells hold the promise to treat not only several congenital and acquired bone degenerative diseases but also to repair and regenerate morbid bone tissues. Utilizing MSCs, several lines of evidences advocate promising clinical outcomes in skeletal diseases and skeletal tissue repair/regeneration. In this context, both, autologous and(More)
BACKGROUND Hemodialysis (HD)-related lower extremity (LE) muscle cramps are a common cause of morbidity in end-stage renal disease patients on maintenance HD. Numerous pharmacologic and physical measures have been tried with variable success rates. METHODS Sequential compression devices (SCD) improve venous return (VR) and are commonly used to prevent LE(More)
Efforts to build quantum computers using ion-traps have demonstrated all elementary qubit operations necessary for scalable implementation. Modular architectures have been proposed to construct modest size quantum computers with up to 10<sup>4</sup> - 10<sup>6</sup> qubits using technologies that are available today (MUSIQC architecture). Concrete(More)
A systematic approach to the inventory control and classification may have a significant influence on company competitiveness. In practice, all inventories cannot be controlled with equal attention. To efficiently control the inventory items and to determine the suitable ordering policies for them, multi-criteria inventory classification is used. The(More)
BACKGROUND Medicines are a main therapeutic intervention provided within hospitals and their proper use in the outpatient setting is important for patients and the community. The objective of this study was to evaluate drug use patterns in the outpatient departments (OPDs) of two tertiary care hospitals (Bahawal Victoria Hospital and Civil Hospital) in the(More)
The class of lattice wave digital (LWD) filters, which are constructed as a parallel connection of two all-pass branches, is extended beyond the known lowpass, highpass, bandpass, and bandstop designs. The goal is to generate a generic design procedure for LWD filters having an arbitrary number of interlaced passbands and stopbands such that such that in(More)