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heterodimers containing a regulatory subunit (see below) and a 110 kDa catalytic subunit (including 110␣ and Department of Signalling The Babraham Institute 110␤) (Hiles et al., 1992; Hu et al., 1993). Both p110␣ and p110␤ are covalently modified and potently inhibited by Cambridge CB2 4AT United Kingdom the fungal metabolite wortmannin contain a §(More)
The immunosuppressants rapamycin and FK506 bind to the same intracellular protein, the immunophilin FKBP12. The FKB12-FK506 complex interacts with and inhibits the Ca(2+)-activated protein phosphatase calcineurin. The target of the FKBP12-rapamycin complex has not yet been identified. We report that a protein complex containing 245 kDa and 35 kDa(More)
Two highly similar, PtdIns(4,5)P2-selective, G beta gamma-activated PI3Ks were purified from pig neutrophil cytosol. Both were heterodimers, were composed of a 101 kDa protein and either a 120 kDa or a 117 kDa catalytic subunit, and were activated greater than 100-fold by G beta gammas. Peptide sequence-based oligonucleotide probes were used to clone cDNAs(More)
  • Stephen Fisher, Ms Esther Leung, Mr Ryan Chiu, Miss Jenny Yip, Miss Christine, Chi-Ho Cheng +17 others
  • 2006
Acknowledgements The research team would like to take this opportunity to thank everyone who helped this study achieve its objectives. We had received full support from the various parties concerned. In particular, only with the cooperation of staff members of the Centres could this study be possible. On top of their already heavy work duties, the staff(More)
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