Learn More
The first experimental evidence of the Turing pattern was observed by De Kepper and her associates (1990) on the CIMA reaction in an open unstirred gel reactor, almost 40 years after Turing's prediction. Lengyel and Epstein characterized this famous experiment using a system of reaction-diffusion equations. In this paper we report some fundamental analytic(More)
Gene transcription in single cells is inherently a probabilistic process. Even in a hypothetically homogeneous intracellular environment, the stochasticity of transcription would produce fluctuations in the number of transcripts, constituting the phenotypic heterogeneity in cell population. Noise, the variance normalized by the square of the mean, has(More)
Gene expression is the central process in cells, and is stochastic in nature. In this work, we study the mean expression level of, and the expression noise in, a population of isogenic cells, assuming that transcription is activated by two sequential exponential processes of rates κ and λ. We find that the mean expression level often displays oscillatory(More)
The recent in vivo RNA detection technique has allowed real-time monitoring of gene transcription in individual living cells, revealing that genes can be transcribed randomly in a bursting fashion that short periods of rapid production of multiple transcripts are interspersed with relatively long periods of no production. In this work, we utilize the three(More)
Dengue fever is a mosquito-borne viral disease with 100 million people infected annually. A novel strategy for dengue control uses the bacterium Wolbachia to invade dengue vector Aedes mosquitoes. As the impact of environmental heterogeneity on Wolbachia spread dynamics in natural areas has been rarely quantified, we develop a model of differential(More)
of Talks In the multiple authors case, the name with * is the speaker. Abstract: (Preliminary report) We examine the asymptotic states of symmetric solutions to ∆u − grad W (u) = 0, u : R n → R n constructed by Alikakos and Fusco. Here W is equivariant under a finite reflection group and has n + 1 nondegenerate minima. Passing to the limit as x → ∞ in(More)
Mosquitoes are primary vectors of life-threatening diseases such as dengue, malaria, and Zika. A new control method involves releasing mosquitoes carrying bacterium Wolbachia into the natural areas to infect wild mosquitoes and block disease transmission. In this work, we use differential equations to describe Wolbachia spreading dynamics, focusing on the(More)