Mouna Akacha

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Background: Acute injury studies often measure physical ability repeatedly over time through scores that have a finite range. This can result in a faster score change at the beginning of the study than towards the end, motivating the investigation of the rate of change. Additionally, the bounds of the score and their dependence on covariates are often of(More)
This work is motivated by dose-finding studies, where the number of events per subject within a specified study period form the primary outcome. The aim of the considered studies is to identify the target dose for which the new drug can be shown to be as effective as a competitor medication. Given a pain-related outcome, we expect a considerable number of(More)
The Collaborative Ankle Support Trial (CAST) is a longitudinal trial of treatments for severe ankle sprains in which interest lies in the rate of improvement, the effectiveness of reminders and potentially informative missingness. A model is proposed for continuous longitudinal data with non-ignorable or informative missingness, taking into account the(More)
In longitudinal and multivariate settings incomplete data, due to missed visits, dropouts or non-return of questionnaires are quite common. A longitudinal trial in which potentially informative missingness occurs is the Collaborative Ankle Support Trial (CAST). The aim of this study is to estimate the clinical effectiveness of four different methods of(More)
The CLAssification and Data Analysis Group (CLADAG) of the Italian Statistical Society recently organised a competition, the ‘Young Researcher Data Mining Prize’ sponsored by the SAS Institute. This paper was the winning entry and in it we detail our approach to the problem proposed and our results. The main methods used are linear regression, mixture(More)
A biological invasion of non-native plants is spreading into our natural areas and rights-of way. In the present work, Melia azedarach (Meliaceae) known for its high allelopathic potential is used to investigate its biopesticide capacity on the common model used in bioassays: Raphanus sativus (R. sativus). Exposure of R. sativus to M. azedarach(More)
Do we always precisely define the treatment effects that our clinical trial will estimate? Our tenet is that this is not always done, or is done inadequately. This lack of clarity can result in a misalignment among trial objectives, trial design, and statistical methods. We will discuss these challenges and present an improved framework using estimands that(More)
Recurrent events involve the occurrences of the same type of event repeatedly over time and are commonly encountered in longitudinal studies. Examples include seizures in epileptic studies or occurrence of cancer tumors. In such studies, interest lies in the number of events that occur over a fixed period of time. One considerable challenge in analyzing(More)
INTRODUCTION In a previously published study, vildagliptin showed a reduced risk of hypoglycemia versus glimepiride as add-on therapy to metformin at similar efficacy. Glimepiride was titrated from a starting dose of 2 mg/day to a maximum dose of 6 mg/day. It is usually assumed that the increased hypoglycemia with glimepiride was driven by the 6 mg/day(More)