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Comparison of three α‐glucosidase inhibitors for glycemic control and bodyweight reduction in Japanese patients with obese type 2 diabetes

• Hitoshi Sugihara, Mototsugu Nagao, +8 authors Shinichi Oikawa
• Journal of diabetes investigation
• 2014

AIMS/INTRODUCTION α-Glucosidase inhibitors (αGIs) are widely used for the primary treatment of type 2 diabetes. We compared the clinical effects of three αGIs (miglitol, acarbose and voglibose) in… (More)

Practical dietary calorie management, body weight control and energy expenditure of diabetic patients in short-term hospitalization.

• Yasushi Nakajima, Kazumi Sato, +10 authors Shinichi Oikawa
• Journal of atherosclerosis and thrombosis
• 2010

AIM We investigated how dietary management affected body weight (BW) reduction and energy expenditure in obese and normal-weight type 2 diabetic patients. METHODS Type 2 diabetic patients who were… (More)

Selective breeding of mice for different susceptibilities to high fat diet‐induced glucose intolerance: Development of two novel mouse lines, Selectively bred Diet‐induced Glucose intolerance‐Prone…

• Mototsugu Nagao, Akira Asai, +10 authors Shinichi Oikawa
• Journal of diabetes investigation
• 2012

UNLABELLED Aims/Introduction:  The development of type 2 diabetes is primarily due to lifestyle and environmental factors, as well as genetics, as shown by familial clustering. To establish mouse… (More)

Liquid chromatography-tandem mass spectrometry determination of human plasma 1-palmitoyl-2-hydroperoxyoctadecadienoyl-phosphatidylcholine isomers via promotion of sodium adduct formation.

• Shunji K Kato, Kiyotaka Nakagawa, +5 authors Teruo Miyazawa
• Analytical biochemistry
• 2015

Accumulation of phosphatidylcholine hydroperoxide (PCOOH), a primary oxidation product of phosphatidylcholine, in blood plasma has been observed in various pathological conditions, including… (More)

Systemic diseases in elderly dental patients.

• Masahiro Umino, Mototsugu Nagao
• International dental journal
• 1993

Systemic diseases, blood pressure and pulse rate, were investigated in 1012 elderly patients who consulted the gerodontic clinic of Tokyo Medical and Dental University Hospital. One or more systemic… (More)

Low density lipoprotein particle diameter in young, nonobese, normolipidemic Japanese men.

• Tsutomu Kazumi, Akito Kawaguchi, +5 authors Gen Yoshino
• Atherosclerosis
• 1999

BACKGROUND prospective studies have demonstrated that a predominance of small, dense LDL particles (pattern B) precedes the clinical onset of coronary heart disease. Prevalence and characteristics of… (More)

Effect of impaired glucose tolerance on atherosclerotic lesion formation: an evaluation in selectively bred mice with different susceptibilities to glucose intolerance.

• Akira Asai, Mototsugu Nagao, Momoyo Kawahara, Yuki Shuto, Hitoshi Sugihara, Shinichi Oikawa
• Atherosclerosis
• 2013

OBJECTIVE Impaired glucose tolerance (IGT) is an independent risk factor for atherosclerotic cardiovascular disease. However, due to the lack of appropriate animal models, the underlying mechanisms… (More)

Transgenerational changes of metabolic phenotypes in two selectively bred mouse colonies for different susceptibilities to diet-induced glucose intolerance.

• Mototsugu Nagao, Akira Asai, Hitoshi Sugihara, Shinichi Oikawa
• Endocrine journal
• 2015

We recently established 2 mouse lines with different susceptibilities (prone and resistant) to high-fat diet (HFD)-induced glucose intolerance by selective breeding (designated selectively bred… (More)

Fat intake and the development of type 2 diabetes.

• Mototsugu Nagao, Akira Asai, Hitoshi Sugihara, Shinichi Oikawa
• Endocrine journal
• 2015

The increase in the number of patients with diabetes has become a worldwide healthcare issue, with numbers predicted to reach approximately 600 million by 2035. In Asia-Pacific region, the prevalence… (More)

Repetitive Glucose Spikes Accelerate Atherosclerotic Lesion Formation in C57BL/6 Mice

• Yuki Shuto, Akira Asai, Mototsugu Nagao, Hitoshi Sugihara, Shinichi Oikawa, Hiroyuki Itabe
• PloS one
• 2015

BACKGROUND A number of epidemiological studies demonstrated that postprandial hyperglycemia is a risk factor for cardiovascular disease in individuals with impaired glucose tolerance. Although… (More)

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