Motoaki Murakoshi

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Mitochondrial alteration in aged rat adrenal cortical cells were studied. Severe mitochondrial alterations were predominantly observed in the zonae fasciculata and reticularis of the adrenal cortex. Many adrenal cortical mitochondria from these zones were relatively larger in size and more irregular in shape. The matrix of altered mitochondria appeared(More)
Metabolic adaptation to limited supplies of oxygen and nutrients plays a pivotal role in health and disease. Heart attack results from insufficient delivery of oxygen and nutrients to the heart, where cardiomyocytes die and cardiac fibroblasts proliferate--the latter causing scar formation, which impedes regeneration and impairs contractility of the heart.(More)
Localization of glutathione-peroxidase (GSH-PO) in adrenal cortical cells of neonatal rats were determined by immunocytochemical analysis. GSH-PO first appeared 14 days after birth. Intracellular localization of GSH-PO was mainly in cytosol (cytosol GSH-PO) but no intramitochondrial localization of GSH-PO was detected. Twenty-one days after birth,(More)
The correlation between adrenal cortical steroid metabolism and ultrastructural alterations was studied in rat adrenal glands stimulated by 4-aminopyrazolopyrimidine (4-APP) and ACTH. Ultrastructural alterations were focused on the outer fasciculata (Outer zone) and inner fasciculata-reticularis (Inner zone) of the rat adrenal cortical cells. In 4-APP(More)
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