Mostafa Abbasi

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Computational modeling has an important role in design and assessment of medical devices. In computational simulations, considering accurate constitutive models is of the utmost importance to capture mechanical response of soft tissue and biomedical materials under physiological loading conditions. Lack of comprehensive three-dimensional constitutive models(More)
OBJECTIVES Leaflet thrombosis following transcatheter aortic valve replacement (TAVR) and valve-in-valve (ViV) procedures has been increasingly recognized. However, the factors affecting the post-TAVR/ViV thrombosis are not fully understood. This study aimed to investigate the effect of the geometric confinement of transcatheter aortic valve (TAV) on blood(More)
Valvular hemolysis and thrombosis are common complications associated with stenotic heart valves. This study aims to determine the extent to which hemodynamics induce such traumatic events. The viscous shear stress downstream of a severely calcified bioprosthetic valve was evaluated via in vitro 2D particle image velocimetry measurements. The blood cell(More)
BACKGROUND Leaflet thrombosis after valve-in-valve (ViV) procedure has been increasingly recognized. This study aimed to investigate the flow dynamics aspect of leaflet thrombosis by quantifying the blood stasis on the noncoronary and coronary leaflets of a surgical aortic valve (SAV) and a transcatheter aortic valve (TAV) in a ViV setting. METHODS Two(More)
BACKGROUND Transcatheter aortic valve replacement (TAVR) is an established treatment for high-risk patients with severe symptomatic aortic stenosis. It is well-known that leaflet shape has a key role in hemodynamic performance and durability of bioprosthetic valves. Excessive mechanical stress on transcatheter aortic valve (TAV) leaflets may lead to(More)
Transcatheter aortic valve replacement (TAVR) is an established treatment alternative to surgical valve replacement in high-risk patients with severe symptomatic aortic stenosis. The current guidelines for TAVR are to upsize transcatheter aortic valve (TAV) relative to the native annulus to secure the device and minimize paravalvular leakage. Unlike(More)
TCT-656 Prolong Blood Stasis on Transcatheter Aortic Valve Leaflets as a Possible Mechanism for Thrombogenesis Koohyar Vahidkhah, Mohammad Barakat, Mostafa Abbasi, Shahnaz Javani, Peyman Azadani, Anwar Tandar, Danny Dvir, Ali Azadani University of Denver, Denver, Colorado, United States; University of Denver; University of Denver, Denver, Colorado, United(More)
AIMS There is an increasing awareness of leaflet thrombosis following transcatheter aortic valve implantation (TAVI) and valve-in-valve (ViV) procedures. Nevertheless, the predisposing factors affecting transcatheter aortic valve (TAV) thrombosis have remained unclear. This study quantifies the effects of reduced cardiac output (CO) on blood stasis on the(More)
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