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1. Purkinje cells (PCs) from guinea-pig cerebellar slices were physiologically characterized using intracellular techniques. Extracellular caesium ions were used to linearize the membrane properties of PCs near the resting potential. Under these conditions the average input resistance, RN, was 29 M omega, the average system time constant, tau 0, was 82 ms(More)
Simultaneous recordings from the soma and apical dendrite of layer V neocortical pyramidal cells of young rats show that, for any location of current input, an evoked action potential (AP) always starts at the axon and then propagates actively, but decrementally, backward into the dendrites. This back-propagating AP is supported by a low density (-gNa =(More)
That the cerebral cortex processes information at prodigious speeds cannot be doubted. Yet the passive time constant, tau(m), of neurons, often thought of as a measure of the neuron's "response time' to synaptic input, is relatively long. In the 1950s, tau(m) was estimated to be only a few milliseconds for mammalian central neurons; with improvement in(More)
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