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Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination
- C. Lucchinetti, W. Brück, J. Parisi, B. Scheithauer, Moses Rodriguez, H. Lassmann
- Medicine, BiologyAnnals of neurology
- 1 June 2000
At a given time point of the disease, the patterns of demyelination were heterogeneous between patients, but were homogenous within multiple active lesions from the same patient, suggesting that MS may be a disease with heterogeneous pathogenetic mechanisms.
Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls
This study is consistent with the hypothesis that MS patients have gut microbial dysbiosis and further study is needed to better understand their role in the etiopathogenesis of MS.
A randomized trial of plasma exchange in acute central nervous system inflammatory demyelinating disease
Plasma exchange leads to functionally important neurological recovery in an important proportion of severely disabled patients with acute attacks of idiopathic inflammatory demyelinating disease, and was sustained on follow‐up.
The relevance of animal models in multiple sclerosis research.
Distinct Patterns of Multiple Sclerosis Pathology Indicates Heterogeneity in Pathogenesis
A new classification scheme of lesional activity on the basis of the molecular composition of myelin degradation products in macrophages is presented and it is indicated, that the demyelinated plaques of multiple sclerosis may reflect a common pathological end point of a variety of different immunological mechanisms ofMyelin destruction in this disease.
Relation between humoral pathological changes in multiple sclerosis and response to therapeutic plasma exchange
Beneficial plasma exchange response in central nervous system inflammatory demyelination.
Clinical and radiographic features that may aid in identifying patients with fulminant, steroid-refractory central nervous system inflammatory demyelinating disease attacks who are more likely to respond to PLEX are identified.
Clinical implications of benign multiple sclerosis: A 20‐year population‐based follow‐up study
- S. Pittock, Robyn L. McClelland, Moses Rodriguez
- Medicine, PsychologyAnnals of neurology
- 1 August 2004
It is found that the longer the duration of MS and the lower the disability, the more likely a patient is to remain stable and not progress.
Primary demyelination in transgenic mice expressing interferon-γ
- M. Horwitz, C. Evans, D. McGavern, Moses Rodriguez, M. Oldstone
- Biology, MedicineNature Medicine
- 1 September 1997
A direct role for IFN-γ is demonstrated as an inducer of CNS demyelination leading to disease and new opportunities for dissecting the mechanism of demyElination are provided.
Seizures in Patients with Multiple Sclerosis
The pathological underpinning of seizures in MS remains indeterminate, but the prognosis of epilepsy in patients with MS remains uncertain, with some studies suggesting a more favourable prognosis than others.