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We evaluated the resting electroencephalogram (EEG) of 50 first-episode schizophrenia patients and 55 of their relatives, 31 first-episode bipolar patients and 35 of their relatives, and 113 nonpsychiatric subjects and 42 of their relatives. The frequency characteristics of the EEG showed moderate stability for a subgroup of these subjects (n = 106) who(More)
BACKGROUND This study investigated the clinical and biological concomitants of electroencephalogram power abnormalities in schizophrenia. METHODS We examined the power characteristics of resting electroencephalograms in 112 schizophrenic patients. Also collected were measures of psychotic symptomatology, brain morphology, ocular motor functioning,(More)
We examined the frequency characteristics of the electroencephalogram (EEG) in 102 schizophrenic patients (44 first-episode and 58 chronic patients) and 102 normal comparison subjects. EEGs of schizophrenic patients had more delta (1-3 Hz) and theta (3.125-8 Hz) activity and less alpha (8.125-13 Hz) activity than normal comparison subjects. There were no(More)
It is not known whether the magnitude of the structural brain abnormalities that underlie schizophrenia is a determinant of the extent to which patients respond to antipsychotic medication. This study was undertaken in order to explore this relationship. Twenty-six patients receiving treatment for a first episode of psychosis were involved in both a study(More)
We evaluated the temporal stability of smooth-pursuit eye tracking in 38 schizophrenic, 42 nonschizophrenic psychotic (bipolar, depressive, paranoid psychotic, and schizophreniform), and 49 normal subjects. Pursuit performance was evaluated on two testing occasions separated by approximately 9.5 months. Retest reliability coefficients of root mean square(More)
We evaluated the handedness of 58 schizophrenia patients and 54 of their relatives, 23 patients with major depression with psychosis and 24 of their relatives, 36 patients with bipolar psychosis and 33 of their relatives, and 119 nonpsychiatric subjects and 42 of their relatives. Computerized tomography measures were also available for a subset of the(More)
Schizophreniform disorder, a potentially useful construct, is difficult to operationalize either for clinical or research purposes. According to DSM-III-R, schizophreniform disorder is descriptively identical to schizophrenia, differing only in duration of symptoms. This study suggests several features that, at initial examination, differentiate(More)
OBJECTIVE To determine optimal doses of haloperidol for the treatment of a first episode of psychosis. METHOD A 4-week prospective controlled clinical trial with "optimal dose" defined as the dose at which either of the following occurs: 1) significant improvement, defined as a 15% or greater decrease in scores on the Positive And Negative Syndrome Scale(More)
Status of Women Canada is committed to ensuring that all research produced through the Policy Research Fund adheres to high methodological, ethical and professional standards. Specialists in the field anonymously review each paper and provide comments on: • the accuracy, completeness and timeliness of the information presented; • the extent to which the(More)
BACKGROUND Prior research suggested that time splitting--suppressing the past and dissociating it from present and future--protected refugee mental health in the aftermath of catastrophe. The current study investigates temporal reintegration, defined as cognitive recapture of the past and reconnecting it with present and future, the mental health effects of(More)