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We evaluated the resting electroencephalogram (EEG) of 50 first-episode schizophrenia patients and 55 of their relatives, 31 first-episode bipolar patients and 35 of their relatives, and 113 nonpsychiatric subjects and 42 of their relatives. The frequency characteristics of the EEG showed moderate stability for a subgroup of these subjects (n = 106) who(More)
BACKGROUND This study investigated the clinical and biological concomitants of electroencephalogram power abnormalities in schizophrenia. METHODS We examined the power characteristics of resting electroencephalograms in 112 schizophrenic patients. Also collected were measures of psychotic symptomatology, brain morphology, ocular motor functioning,(More)
One hundred eighteen psychiatric patients, each experiencing his or her first lifetime episode of psychosis, 125 of their first-degree relatives, and 155 normal subjects were assessed using the physical anhedonia, social anhedonia, and perceptual aberration scales of Chapman et al. (1976, 1978). We hypothesized that psychotic subjects would obtain higher(More)
We examined the frequency characteristics of the electroencephalogram (EEG) in 102 schizophrenic patients (44 first-episode and 58 chronic patients) and 102 normal comparison subjects. EEGs of schizophrenic patients had more delta (1-3 Hz) and theta (3.125-8 Hz) activity and less alpha (8.125-13 Hz) activity than normal comparison subjects. There were no(More)
We evaluated the temporal stability of smooth-pursuit eye tracking in 38 schizophrenic, 42 nonschizophrenic psychotic (bipolar, depressive, paranoid psychotic, and schizophreniform), and 49 normal subjects. Pursuit performance was evaluated on two testing occasions separated by approximately 9.5 months. Retest reliability coefficients of root mean square(More)
OBJECTIVE To determine optimal doses of haloperidol for the treatment of a first episode of psychosis. METHOD A 4-week prospective controlled clinical trial with "optimal dose" defined as the dose at which either of the following occurs: 1) significant improvement, defined as a 15% or greater decrease in scores on the Positive And Negative Syndrome Scale(More)
Canada admits between more than 200,000 immigrants every year. National policy emphasizes rigorous selection to ensure that Canada admits healthy immigrants. However, remarkably little policy is directed to ensuring that they stay healthy. This neglect is wrong-headed: keeping new settlers healthy is just, humane, and consistent with national self-interest.(More)
We evaluated the handedness of 58 schizophrenia patients and 54 of their relatives, 23 patients with major depression with psychosis and 24 of their relatives, 36 patients with bipolar psychosis and 33 of their relatives, and 119 nonpsychiatric subjects and 42 of their relatives. Computerized tomography measures were also available for a subset of the(More)
BACKGROUND Prior research suggested that time splitting--suppressing the past and dissociating it from present and future--protected refugee mental health in the aftermath of catastrophe. The current study investigates temporal reintegration, defined as cognitive recapture of the past and reconnecting it with present and future, the mental health effects of(More)
The United States is a country of immigrants. With the exception of Native-Americans, every other American is, or descends from, an immigrant. First and second generation immigrant children are the most rapidly growing segment of the American population, with the great majority of this population being of non-European origin. This paper reviews the unique(More)