Learn More
The presence/absence of stromal metachromasia, at the zone of host-tumour interaction, was recorded in 220 primary breast carcinomas. This reaction, which is associated with an infiltrative as opposed to an expansive growth form, was more common in primaries removed in the first half of the year than the second. This adds to previous evidence based on(More)
Recurrence occurred earlier in a small group of patients with node-negative breast carcinoma with oestrogen receptor (ER)-negative tumours, than in those in whom the tumour contained ER. The difference, indicative of an intrinsic advantage of an ER-positive tumour, was not seen following adjuvant chemotherapy. This finding could be explained on the basis of(More)
Biopsies or mastectomy specimens from 69 malignant and 17 non-malignant human breast tumours have been examined with respect to cytoplasmic oestradiol receptors and endogenous oestradiol concentration. Of the malignant tumours, 45 (65%) had significant oestradiol receptor concentrations (136.7 fmol/mg protein +/- 38.3 S.E.M.). Oestradiol values in the(More)
The prognostic value of oestrogen receptor analysis is demonstrated in 150 patients with infiltrating breast carcinoma. Recurrence of tumour was earlier and more frequent in the receptor negative than in the receptor positive cases. There was more early deaths in the receptor negative group. The mean follow-up time was 30 months.
Evidence is presented that the growth rate of breast carcinomas in a defined population was lower in January and June than in the later months of the year. The tumours presenting later were on average larger and of higher histological grade. While there was no difference in the distribution of oestrogen receptor (ER) status, the receptor positive showed(More)
Study of all lymph nodes removed from the axillary dissection specimens from 37 node-negative and 22 node-positive breast cancer patients showed that the number of nodes present in the specimen increased with the diameter of the primary tumor up to 4 cm. Larger tumors showed fewer nodes. The majority of the tumorbearing nodes were in the middle and lower(More)
Histological grading of 160 primary infiltrating breast carcinomas showed that both oestrogen and progesterone receptor status are strongly related to grade, tumours that are receptor positive tending to be of lower grade than the receptor negative. The nuclear factors used in grading were those that determined this association. In addition the(More)
This paper reports a difference in the lymphoid tissue area in the axilla of node-negative breast cancer patients in the first versus the second half of the year, the area being greater in the latter. This observations is new. It is based on data from 72 patients derived over 25 consecutive months and is in keeping with previous reports of a proliferative(More)
Histological grading of 126 oestrogen receptor positive and 81 oestrogen receptor negative breast carcinomas, using the WHO system, showed that some tumours in all grades had high receptor values, others low. There was no correlation between the receptor values and histological grade. It is suggested that factors other than the degree of dedifferentiation(More)