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Morbidity and mortality in patients randomised to double-blind treatment with a long-acting calcium-channel blocker or diuretic in the International Nifedipine GITS study: Intervention as a Goal in
TLDR
Nifedipine once daily and co-amilozide were equally effective in preventing overall cardiovascular or cerebrovascular complications in high-risk patients with hypertension.
Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial
TLDR
Spironolactone was the most effective blood pressure-lowering treatment, throughout the distribution of baseline plasma renin; but its margin of superiority and likelihood of being the best drug for the individual patient were many-fold greater in the lower than higher ends of the distribution.
British Hypertension Society guidelines for hypertension management 2004 (BHS-IV): summary
TLDR
This guideline reinforces the view that doctors should not focus solely on blood pressure but must also formally assess total risk of cardiovascular disease and use multifactorial interventions, including statins and aspirin, to reduce it.
Renin‐angiotensin system gene polymorphisms influence blood pressure and the response to angiotensin converting enzyme inhibition
TLDR
Although it did not influence pretreatment blood pressure in this population, AGT genotype was an independent predictor of the blood pressure response to ACE inhibition, with an apparent interaction between these two gene loci.
Blood pressure loci identified with a gene-centric array.
TLDR
An analysis of combined discovery and follow-up data identified SNPs significantly associated with BP at p < 8.56 × 10(-7) at four further loci and highlighted the utility of studying SNPs and samples that are independent of those studied previously even when the sample size is smaller than that in previous studies.
Aldehyde Dehydrogenase 2 Plays a Role in the Bioactivation of Nitroglycerin in Humans
TLDR
The findings suggest that ALDH2 is involved in the bioactivation of NTG in humans in vivo but accounts for less than half of the total bioactivation.
Atenolol and eprosartan: differential effects on central blood pressure and aortic pulse wave velocity.
TLDR
Comparing the hemodynamic effects of atenolol and eprosartan in a double-blind, randomized, cross-over study indicates that despite similar effects on peripheral BP and a greater effect on aortic stiffness, atanolol had less impact on central systolic BP than e Prosesartan because it failed to reduce wave reflection.
Aliskiren and the calcium channel blocker amlodipine combination as an initial treatment strategy for hypertension control (ACCELERATE): a randomised, parallel-group trial
TLDR
It is believed that routine initial reduction in blood pressure with a combination such as aliskiren plus amlodipine can be recommended and should be recommended.
Renin: friend or foe?
TLDR
Being a large and stable molecule, renin is among the easiest and cheapest of hormone measurements, and understanding the simple biochemistry and physiology of renin permits optimal use of the drugs acting to raise or suppress this hormone.
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