Moritz Aschoff

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MOTIVATION Alternative splicing is central for cellular processes and substantially increases transcriptome and proteome diversity. Aberrant splicing events often have pathological consequences and are associated with various diseases and cancer types. The emergence of next-generation RNA sequencing (RNA-seq) provides an exciting new technology to analyse(More)
The calibration of complex models of biological systems requires numerical simulation and optimization procedures to infer undetermined parameters and fit measured data. The optimization step typically employs heuristic global optimization algorithms, but due to measurement noise and the many degrees of freedom, it is not guaranteed that the identified(More)
The calibration of complex models of biological systems requires numerical simulation and optimization procedures to infer undetermined parameters and fit measured data. The optimization step typically employs heuristic global optimization algorithms, but due to measurement noise and the many degrees of freedom, it is not guaranteed that the identified(More)
The armadillo repeat protein ARVCF is a component of adherens junctions. Similar to related proteins, such as p120-catenin and β-catenin, with known signaling functions, localization studies indicate a cytoplasmic and a nuclear pool of ARVCF. We find that ARVCF interacts with different proteins involved in mRNA-processing: the splicing factor SRSF1(More)
The gold standard in determination of cardiac output is highly invasive and expensive in use. An accurate and reliable method, non-invasively and affordable, would improve hemodynamic management. This study is for validation of a new module in impedance cardiography to improve the accuracy in cardiac patients. Heart rate, Cardiac output/ index, and stroke(More)
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