Skip to search formSkip to main contentSkip to account menu
Cocaine versus food choice procedure in rats: environmental manipulations and effects of amphetamine.
TLDR
The results suggest feasibility and utility of the choice procedure in rats and support its comparability to similar procedures used in humans and monkeys.
View on PubMed
Nicotine-like behavioral effects of the minor tobacco alkaloids nornicotine, anabasine, and anatabine in male rodents.
TLDR
Results suggest that the minor tobacco alkaloids may substitute for the subjective effects of nicotine and attenuate withdrawal and craving without the abuse liability of nicotine.
View on PubMed
Dramatically Decreased Cocaine Self-Administration in Dopamine But Not Serotonin Transporter Knock-Out Mice
TLDR
Findings support the notion that the DAT, but not the SERT, is critical in mediating the reinforcing effects of cocaine.
View on Publisher
Lack of Self-Administration of Cocaine in Dopamine D1 Receptor Knock-Out Mice
TLDR
It is concluded that D1 receptor knock-out mice do not reliably self-administer cocaine and that the D1ceptor is critical for the reinforcing effects of cocaine and other dopamine agonists, but not food or opioids, in mice.
View on Publisher
Chronic Intravenous Drug Self‐Administration in Rats and Mice
TLDR
This unit focuses on recent technical innovations for conducting long‐term studies of i.v. drug self‐administration behavior in healthy, freely moving rats and mice.
View on Wiley
Lack of Cocaine Self-Administration in Mice Expressing a Cocaine-Insensitive Dopamine Transporter
TLDR
It is shown that mice expressing a “knockin” of a cocaine-insensitive but functional DAT did not self-administer cocaine intravenously despite normal food-maintained responding and normal intravenous self-administration of amphetamine and a direct dopamine agonist.
View on Publisher
Intravenous Drug Self-administration in Mice: Practical Considerations
TLDR
Techniques for successfully conducting self-administration studies in mice are described, including advantages, disadvantages and possible implications of employing various experimental approaches, and how the genetic background on which mutations are expressed may influence results from gene-targeting studies are reviewed.
View on Springer
Role for M5 muscarinic acetylcholine receptors in cocaine addiction
TLDR
Results demonstrate that M5 receptors play an important role in mediating both cocaine‐associated reinforcement and withdrawal, and the severity of the cocaine withdrawal syndrome was significantly attenuated in mice lacking the M5 receptor.
View on Wiley
Effects of acute and chronic aripiprazole treatment on choice between cocaine self-administration and food under a concurrent schedule of reinforcement in rats
TLDR
The results confirm and extend earlier findings and indicate that acute administration of aripiprazole can decrease cocaine self-administration and shift the cocaine choice curve to the right as an acute treatment, and suggest that the concurrent choice procedure in rats has predictive validity of efficacy in humans.
View on Springer
Reduced Cocaine Self-Administration in Muscarinic M5 Acetylcholine Receptor-Deficient Mice
TLDR
The results indicate that M5 receptor deletion diminished the reinforcing effects of low doses of cocaine and identified specific conditions under which this may be observed.
View on Publisher
...
...
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License