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  • N. Janicic, E. Soliman, +5 authors G. N. Hendy
  • 1995
The calcium-sensing receptor (CASR), a member of the G-protein coupled receptor family, is expressed in both parathyroid and kidney, and aids these organs in sensing extracellular calcium levels. Inactivating mutations in the CASR gene have been described in familial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT).(More)
BACKGROUND In an attempt to better understand and define the progression of amyotrophic lateral sclerosis (ALS), we developed a classification of 5 discrete health states that reflect patients' activities of daily living. These health states were used to determine whether patients with ALS who are treated with riluzole differed from those treated with(More)
Research of new diagnosis or prognosis biomarkers is a major challenge for the management of patients with complex pathologies like cancer. Clinical proteomics is one of the recent approaches to identify these biomarkers in biological fluids. Over the last five years, many problems related to the variability and the quality control of these analyses have(More)
Mammary tumors were promoted in male rats of the Wistar WAG strain by continuous and simultaneous administration of 17 beta-estradiol and progesterone. Tumor induction and growth were dependent on estradiol and on progesterone. Their histological features were comparable with those of human breast cancers. Hormone receptors were present in tumor cells.(More)
  • C. Szpirer, J. Szpirer, +4 authors R. Schäfer
  • 1996
The laboratory rat, whose genetic map is developing significantly (Yamada et al. 1994; Jacob et al. 1995; Klinga-Levan et al. 1996; Pravenec et al. 1996), is used as a model organism for elucidating the mechanisms of cancer initiation mediated by mutated ras oncogenes (Sukumar et al. 1983). To identify candidate tumor suppressor genes of HRAS-mediated(More)
  • C. Szpirer, J. Szpirer, M. Rivière, G. Levan, J. Orlowski
  • 1994
The plasma membrane Na/H exchanger plays an essential role in regulating intracellular pH and Na+ concentration and has been implicated in several pathophysiological conditions, including essential hypertension and congenital secretory diarrhea. Four isoforms of the Na/H exchanger encoded by separate genes have recently been identified by cDNA cloning. To(More)
Ultrasound examination of a 31-year-old woman at 27 weeks' gestation revealed fetal growth retardation, a bilateral cleft lip and palate, and the absence of median cerebral structures. Chromosome analysis after cordocentesis showed an abnormal karyotype with a structural abnormality of the long arm of chromosome 7: 46,XX,-7,+der(7),t(7;18) (q34;q21.3)mat.(More)
  • C. Szpirer, F. Tissir, M. Rivière, G. Levan, J. Szpirer
  • 1994
By means of somatic cell hybrids segregating rat chromosomes, we determined the chromosome localization of three rat genes of the Jun family: Jumb (Chr 19), Jun (=c-Jun) (Chr 5) and Jund (Chr 16). The Jun gene was also localized to the 5q31–33 region by fluorescence in situ hybridization. These rat gene assignments reveal two new homologies with mouse and(More)