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Cancer-related deregulation of miRNA biogenesis has been suggested, but the underlying mechanisms remain elusive. Here we report a previously unrecognized effect of hypoxia in the downregulation of Drosha and Dicer in cancer cells that leads to dysregulation of miRNA biogenesis and increased tumour progression. We show that hypoxia-mediated downregulation(More)
Improving small interfering RNA (siRNA) efficacy in target cell populations remains a challenge to its clinical implementation. Here, we report a chemical modification, consisting of phosphorodithioate (PS2) and 2'-O-Methyl (2'-OMe) MePS2 on one nucleotide that significantly enhances potency and resistance to degradation for various siRNAs. We find enhanced(More)
Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: Cancer-related deregulation of miRNA biogenesis has been suggested, but the underlying mechanisms remain elusive. Here, we report a previously unrecognized effect of hypoxia in the(More)
PURPOSE XPO1 inhibitors have shown promise for cancer treatment, and yet the underlying mechanisms for the antitumor effects are not well understood. In this study, we explored the usefulness of selective inhibitors of nuclear export (SINE) compounds that are specific inhibitors of XPO1. EXPERIMENTAL DESIGN We used proteomic analysis in XPO1(More)
This paper examines the impact of YouTube on the video content market. Previous research is examined to determine the scope of the online migration thus far and its effect on the traditional video market (television). Analysis of YouTube's user data and earnings reveals that YouTube has a monopolistically competitive market structure. YouTube's(More)
was one of the earliest pioneers in the field of Biomedical Informatics. He published his first paper, " A mathematical approach to medical diagnosis: Application to congenital heart disease " in JAMA in 1961. He founded the Utah informatics program in the early 1960s and served as its chair until the mid-1990s. Homer passed away on November 30, 2012.(More)
Having a large social network is generally beneficial to health. However, it is unclear how Internet-based social networks might influence health. Chronic stress can have negative health consequences, and some data suggest that Facebook could be a new source of psychological stress. Thus, we examined undergraduate college student perceptions of Facebook use(More)
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