Morgan Jones

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Chromosomal translocations involving the mixed lineage leukemia (MLL) gene lead to the development of acute leukemias. Constitutive HOX gene activation by MLL fusion proteins is required for MLL-mediated leukemogenesis; however, the underlying mechanisms remain elusive. Here, we show that chromobox homolog 8 (CBX8), a Polycomb Group protein that interacts(More)
The purpose of our study was twofold: to better understand the relationship between medial meniscal extrusion (MME) and degenerative joint disease (DJD), and to determine whether a relationship exists between MME and medial meniscal root (MMR) pathology, radial tear and joint effusion. Two hundred and five consecutive MR imaging examinations of the knee(More)
The clinical practice guideline was explicitly developed to include only treatments less invasive than knee replacement (ie, arthroplasty). Patients with symptomatic osteoarthritis of the knee are to be encouraged to participate in self-management educational programs and to engage in self-care, as well as to lose weight and engage in exercise and(More)
Ankle sprains are among the most common athletic injuries and represent a significant source of persistent pain and disability. Despite the high incidence of ankle sprains in athletes, syndesmosis injuries have historically been underdiagnosed, and assessment in terms of severity and optimal treatment has not been determined. More recently, a heightened(More)
Anthony Stentz, Herman Herman, Alonzo Kelly, Eric Meyhofer, G. Clark Haynes, David Stager, Brian Zajac, J. Andrew Bagnell, Jordan Brindza, Christopher Dellin, Michael George, Jose Gonzalez-Mora, Sean Hyde, Morgan Jones, Michel Laverne, Maxim Likhachev, Levi Lister, Matt Powers, Oscar Ramos∗, Justin Ray, David Rice, Justin Scheifflee, Raumi Sidki†,(More)
BACKGROUND Various methods of bony stabilization, including modifications of Bristow and Latarjet procedures, are considered gold-standard treatment for recurrent anterior shoulder instability but are associated with unique complications and risk of reoperation. The purpose of this study was to identify the prevalence of these complications. We hypothesized(More)
OBJECTIVE To evaluate whether a 30-minute decision-to-delivery interval is a realistic target for emergency caesarean section. DESIGN An audit of all emergency caesarean sections over five separate periods. SETTING A district general hospital. PARTICIPANTS Five groups of women (343 women) with an indication for emergency caesarean section. METHODS(More)
PURPOSE The purpose of this study was to evaluate the effect of graft size on patient-reported outcomes and revision risk after anterior cruciate ligament (ACL) reconstruction. METHODS A retrospective chart review of prospectively collected cohort data was performed, and 263 of 320 consecutive patients (82.2%) undergoing primary ACL reconstruction with(More)
Chromosomal translocations affecting mixed lineage leukemia gene (MLL) result in acute leukemias resistant to therapy. The leukemogenic activity of MLL fusion proteins is dependent on their interaction with menin, providing basis for therapeutic intervention. Here we report the development of highly potent and orally bioavailable small-molecule inhibitors(More)
BACKGROUND Hill-Sachs lesions are often present with recurrent shoulder instability and may be a cause of failed Bankart repair. HYPOTHESIS Glenohumeral joint stability decreases with increasingly larger humeral head defects. STUDY DESIGN Descriptive laboratory study. METHODS Humeral head defects, 1/8, 3/8, 5/8, and 7/8 of the humeral head radius,(More)